{
  "abstract": "The pathological microenvironment of acute gouty arthritis (AGA) features local tissue acidification and the release of a storm of pro-inflammatory cytokines. To address this dual challenge, we engineered an acid-responsive curcumin-loaded nanoparticles microneedle system (Cur-PNPs@MN) that delivers curcumin with pH-triggered release and anti-inflammatory activity. This integrated platform combines a hyaluronic acid (HA)-based dissolving microneedle for localized transdermal delivery of acid-degradable PCADK (poly (cyclohexane-1,4-diyl acetone dimethylene ketal)) curcumin nanoparticles (Cur-PNPs), which are designed for pH-triggered curcumin release at the pathological site. Together, they deliver curcumin, a dual-function agent acting both as an anti-inflammatory compound and a nanoenhanced sonosensitizer. In vitro, the system exhibited acid-responsive drug release and also promoted macrophage uptake, achieving significant curcumin accumulation within 1 hour and saturation by 4 hours. Moreover, it could generate potent ultrasound-induced reactive oxygen species (ROS). The ROS generation capability of Cur-PNPs was 1.47-fold higher than that of Cur‑aggregates, resulting in anapoptosis rate of 29.9% in M1 macrophages. In vivo, the chemo-sonodynamic therapy (Cur-PNPs@MN+Ultrasound (US)) in a rat AGA model significantly alleviated joint swelling and inflammatory infiltration, while drastically suppressing pro-inflammatory cytokines, with IL-1β decreasing from 170.3 to 67.3 pg/mL, TNF-α from 20.8 to 5.9 pg/mL, and IL-6 from 140.9 to 48.2 pg/mL, and achieved therapeutic efficacy comparable to conventional drugs. This work demonstrates a synergistic chemo‑sonodynamic strategy by coupling pH-triggered curcumin release with ultrasound-enhanced ROS generation. This acid-responsive therapeutic strategy enhances anti-inflammatory efficacy and reduction of M1-associated inflammatory responses, offering an effective approach for AGA therapy.",
  "abstract_shown": true,
  "affiliations": [
    "College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou, PR China.",
    "Institute of Laser Advanced Manufacturing, Zhejiang University of Technology, Hangzhou, PR China.",
    "College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China.",
    "Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School, Shanghai, PR China.",
    "Ingénierie des Matériaux Polymères, Université Lyon 1, INSA Lyon, Université Jean Monnet, CNRS, UMR 5223, Villeurbanne, France."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jiaqi Weng"
    },
    {
      "affs": [
        3
      ],
      "name": "Lili Feng"
    },
    {
      "affs": [
        2
      ],
      "name": "Binghui Xie"
    },
    {
      "affs": [
        2
      ],
      "name": "Linxiao Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Shulin Shen"
    },
    {
      "affs": [
        2
      ],
      "name": "Xuechao Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Liting Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yueyue Xie"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jianhua Yao"
    },
    {
      "affs": [
        4
      ],
      "name": "Laurent David"
    },
    {
      "affs": [
        2
      ],
      "name": "Qinying Yan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/21a2xkjmwt39b.bib",
  "cited_by": 0,
  "doi": "10.1080/10717544.2026.2743337",
  "fulltext_url": "https://europepmc.org/articles/PMC13670771",
  "id": "21a2xkjmwt39b",
  "issns": [
    "1071-7544",
    "1521-0464"
  ],
  "landing_url": "https://europepmc.org/article/MED/42868112",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Nanoplatforms for cancer theranostics"
    ]
  ],
  "openalex": "W7221690253",
  "pdf_url": "https://europepmc.org/articles/PMC13670771?pdf=render",
  "pmcid": "PMC13670771",
  "pmid": "42868112",
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/21a2xkjmwt39b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42868112",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42868112"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:3003|Advanced Drug Delivery Systems",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Acid-responsive nanoparticles with microneedles for anti‑inflammatory sonodynamic therapy of gouty arthritis.",
  "title_text": "Acid-responsive nanoparticles with microneedles for anti‑inflammatory sonodynamic therapy of gouty arthritis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/21a2xkjmwt39b",
  "venue": "Drug delivery",
  "versions": []
}