{
  "abstract": "Airway hyperresponsiveness (AHR) is a key physiological feature of asthma and contributes to excessive airway narrowing in response to diverse stimuli. Although asthma-related airway physiology exhibits marked temporal variation, whether AHR itself is independently regulated by the endogenous circadian clock remains unclear. In this narrative review, we summarize current evidence on the definition and temporal phenotype of AHR, with particular emphasis on distinguishing clock-time variation from endogenous circadian regulation and on direct evidence from bronchial provocation studies. We further discuss potential mechanisms linking circadian biology to AHR, including neuroendocrine and autonomic gating, epithelial-immune temporal coupling, airway smooth muscle reactivity, and metabolic and redox regulation. Current evidence supports substantial time dependence of asthma-related airway physiology, whereas direct evidence for an intrinsic circadian rhythm of AHR in humans remains limited with mechanistic insights derived predominantly from animal, ex vivo, and cellular studies. We also review time-dependent treatment strategies, particularly inhaled corticosteroid (ICS) administration, while distinguishing clinically investigated dosing schedules from experimental clock-targeted interventions. Overall, circadian biology provides a framework for understanding temporal variation in AHR and may inform future approaches to phenotyping and treatment timing; however, circadian-based AHR management and clock-targeted therapies remain investigational and require validation in well-controlled human studies.",
  "abstract_shown": true,
  "affiliations": [
    "The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chang Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyue Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Lijuan Zeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Tang",
      "orcid": "0009-0005-8315-9336"
    },
    {
      "affs": [
        0
      ],
      "name": "Chuxian Yi"
    },
    {
      "affs": [
        0
      ],
      "name": "Guomin Zhang",
      "orcid": "0009-0004-6538-4727"
    },
    {
      "affs": [
        0
      ],
      "name": "Sujuan Peng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/221gde2r56m32.bib",
  "cited_by": 0,
  "doi": "10.1002/clt2.70221",
  "fulltext_url": "https://europepmc.org/articles/PMC13744419",
  "id": "221gde2r56m32",
  "issns": [
    "2045-7022"
  ],
  "landing_url": "https://europepmc.org/article/MED/42998305",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7225463590",
  "pdf_url": "https://europepmc.org/articles/PMC13744419?pdf=render",
  "pmcid": "PMC13744419",
  "pmid": "42998305",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/221gde2r56m32.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42998305",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42998305"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Asthma and respiratory diseases",
      "subfield": "general"
    }
  ],
  "title": "Time-of-Day Variation in Airway Hyperresponsiveness in Asthma: Potential Circadian Mechanisms and Translational Implications.",
  "title_text": "Time-of-Day Variation in Airway Hyperresponsiveness in Asthma: Potential Circadian Mechanisms and Translational Implications.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/221gde2r56m32",
  "venue": "Clinical and translational allergy",
  "versions": []
}