{
  "abstract": "While autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) are relatively rare before the age of 65 (<1%), their prevalence reaches 2–3% between 70 and 80 years and >6% in individuals above 80 years in the general population. To assess the prevalence of IFN-I auto-Abs at the extreme end of human lifespan, we performed a multinational study of centenarians from four geographically and ethnically distinct cohorts collected in Denmark (n = 258), Colombia (n = 99), Australia (n = 281), and Japan (n = 300), comprising 938 individuals. Across cohorts, 51/938 centenarians (5.4%) harbored auto-Abs neutralizing IFN-I, ranging from 3.3% (Japan) to 9.1% (Colombia). We found that the prevalence of IFN-I auto-Abs levels off in centenarians compared with individuals ≥80 years from the general population, demonstrating that neutralizing IFN-I auto-Abs are not incompatible with longevity, despite conferring a risk of life-threatening viral infections. Yet, the plateau of their prevalence in centenarians suggests that they may not be beneficial for reaching exceptional longevity and may negatively impact mortality.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedicine, Aarhus University, Aarhus, Denmark",
    "Center for Immunology of Viral Infections, Aarhus University, Aarhus, Denmark",
    "Laboratory of Human Genetics of Infectious Diseases, Institut Imagine, Université Paris Cité, Necker Branch, INSERM UMR 1163, Paris, France",
    "Paris City University, Imagine Institute, Paris, France",
    "Pediatric Hematology-Immunology & Rheumatology Unit, Necker Hospital for Children, Assistance Publique-Hôpitaux de Paris, Paris, France",
    "Department of Public Health, Danish Aging Research Center, University of Southern Denmark, Odense, Denmark",
    "Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan",
    "Discipline of Psychiatry & Mental Health School of Clinical Medicine, Faculty of Medicine and Health, Centre for Healthy Brain Ageing, UNSW Sydney, Sydney, Australia",
    "Department of Pediatrics, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France",
    "Center for Healthy Longevity, Universidad de la Costa, Barranquilla, Colombia",
    "Colombian Centenarian Alliance, Bogotá, Colombia",
    "Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan",
    "Human Biology Microbiome Quantum Research Center (Bio2Q), Keio University, Tokyo, Japan",
    "Laboratory of Human Genetics of Infectious Diseases, Center for the Genetics of Host Defense, University of Texas Southwestern, Dallas, TX, USA",
    "Departments of Pediatrics and Immunology, and Children Research Institute, University of Texas Southwestern, Dallas, TX, USA",
    "Howard Hughes Medical Institute, New York, NY, USA",
    "Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Nanna Mørk",
      "orcid": "0009-0003-9848-3425"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Julie A. Jensen",
      "orcid": "0009-0002-9704-5442"
    },
    {
      "affs": [
        2,
        3,
        4
      ],
      "name": "Paul Bastard",
      "orcid": "0000-0002-5926-8437"
    },
    {
      "affs": [
        5
      ],
      "name": "Lisbeth Aagaard Larsen",
      "orcid": "0000-0002-0426-0569"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Bettina Bundgaard",
      "orcid": "0009-0004-6979-4256"
    },
    {
      "affs": [
        5
      ],
      "name": "Marianne Nygaard",
      "orcid": "0000-0003-0703-2665"
    },
    {
      "affs": [
        5
      ],
      "name": "Signe Bedsted Clemmensen",
      "orcid": "0000-0001-9871-149X"
    },
    {
      "affs": [
        6
      ],
      "name": "Chiaki Tao",
      "orcid": "0009-0007-9676-8688"
    },
    {
      "affs": [
        7
      ],
      "name": "Vibeke Sorensen Catts",
      "orcid": "0000-0002-9892-0547"
    },
    {
      "affs": [
        2,
        3,
        8
      ],
      "name": "Anne Puel",
      "orcid": "0000-0003-2603-0323"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Guillaume Vogt",
      "orcid": "0000-0001-8192-1247"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Ivan David Lozada-Martinez",
      "orcid": "0000-0002-1960-7334"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Juan-Manuel Anaya",
      "orcid": "0000-0002-6444-1249"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Yasumichi Arai",
      "orcid": "0000-0003-1746-965X"
    },
    {
      "affs": [
        7
      ],
      "name": "Perminder Singh Sachdev",
      "orcid": "0000-0002-9595-3220"
    },
    {
      "affs": [
        6
      ],
      "name": "Satoshi Okada",
      "orcid": "0000-0002-4622-5657"
    },
    {
      "affs": [
        2,
        3,
        13,
        14,
        15
      ],
      "name": "Jean-Laurent Casanova",
      "orcid": "0000-0002-7782-4169"
    },
    {
      "affs": [
        5
      ],
      "name": "Kaare Christensen",
      "orcid": "0000-0002-5429-5292"
    },
    {
      "affs": [
        2,
        3,
        13,
        14
      ],
      "name": "Aurélie Cobat",
      "orcid": "0000-0001-7209-6257"
    },
    {
      "affs": [
        0,
        1,
        16
      ],
      "name": "Trine H. Mogensen",
      "orcid": "0000-0002-1853-9704"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/224dp253g5n5b.bib",
  "cited_by": 0,
  "doi": "10.70962/jhi.20260143",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13712330/",
  "id": "224dp253g5n5b",
  "issns": [
    "3065-8993"
  ],
  "landing_url": "https://doi.org/10.70962/jhi.20260143",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Autoimmunity"
    ],
    [
      "heading",
      "Disorders of Cytokines"
    ],
    [
      "heading",
      "Infections and Auto-Antibodies"
    ],
    [
      "heading",
      "Phenocopies of Inborn Errors"
    ],
    [
      "openalex",
      "2403|interferon and immune responses"
    ]
  ],
  "openalex": "W7223954698",
  "pdf_url": "https://rupress.org/jhi/article-pdf/3/1/e20260143/2043385/jhi_20260143.pdf",
  "pmcid": "PMC13712330",
  "pmid": "42944855",
  "published": "2026-10-27",
  "publisher": "The Rockefeller University Press",
  "ris": "https://research.draconitic.com/paper/224dp253g5n5b.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:56Z",
      "native_id": "PMC13712330",
      "source": "pmc",
      "url": "https://doi.org/10.70962/jhi.20260143"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|interferon and immune responses",
      "subfield": "immunology"
    }
  ],
  "title": "The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians",
  "title_text": "The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:56Z",
  "url": "https://research.draconitic.com/paper/224dp253g5n5b",
  "venue": "Journal of Human Immunity",
  "versions": []
}