{
  "abstract": "Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common immune-mediated demyelinating polyneuropathy, yet data from Arab populations are scarce. We present the first multicenter retrospective Arab cohort describing demographic, clinical, electrophysiological features, and treatment outcomes of CIDP.\n\nMethods: Electronic records from five hospitals in Saudi Arabia were searched between January 2014 and January 2025 for patients diagnosed with CIDP. Patients meeting 2021 EAN/PNS criteria, aged 3 to 80 years, with a minimum follow-up of 3 months were included. Outcome at initial and last visit assessed using MRCSS and INCAT disability scores, with minimal clinically important differences defined as a 4-point and 1-point change in each score, respectively.\n\nResults: Thirty-six (18 male, 18 female) met criteria (33 CIDP,3 possible CIDP). Onset age averaged 33 years (40 years in adult-onset cases). Typical CIDP was predominant (72%), with distal, motor-predominant, and multifocal variants representing 8% each. All motor demyelinating features were upper limb predominant. Maintenance monotherapy, mainly IVIG (42%) or oral steroids (33%), was used to treat 75% of patients. Over 55 months, meaningful improvement was achieved in 89% (INCAT) and 83% (MRCSS) with 3.7- and 11.9-point changes, respectively ( p < 0.001). Relapses occurred in 42% at a mean of 11 months, mostly due to suboptimal response or non-compliance.\n\nConclusion: This is the first Arab multicenter CIDP study, which shows earlier disease onset than North American and European cohorts, with a similar clinical phenotype. Despite a 42% relapse rate, most patients showed meaningful improvement. These findings provide a regional benchmark for future prospective studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, College of Medicine, King Saud University , ,",
    "National Neuroscience Institute, King Fahad Medical City , ,",
    "Department of Neurology, Faculty of Medicine, King Abdulaziz University , ,",
    "Department of Pediatrics, Faculty of Medicine, King Abdulaziz University , ,",
    "Prince Sultan Military Medical City , ,",
    "Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University , ,",
    "Department of Neurology, King Fahad Specialist Hospital , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Reem M. Alhammad"
    },
    {
      "affs": [
        1
      ],
      "name": "Abdulrahman Ali"
    },
    {
      "affs": [
        1
      ],
      "name": "Roula Alhadyan"
    },
    {
      "affs": [
        2
      ],
      "name": "Ahmad R. Abuzinadah"
    },
    {
      "affs": [
        3
      ],
      "name": "Ahmed K. Bamaga"
    },
    {
      "affs": [
        4
      ],
      "name": "Muteb Alotaibi"
    },
    {
      "affs": [
        4
      ],
      "name": "Rawan Albalawi"
    },
    {
      "affs": [
        4
      ],
      "name": "Raseel Aljthalin"
    },
    {
      "affs": [
        5
      ],
      "name": "Raed Gasemaltayeb"
    },
    {
      "affs": [
        6
      ],
      "name": "Talal M. Al-Harbi"
    },
    {
      "affs": [
        6
      ],
      "name": "Faisal Tarabzouni"
    },
    {
      "affs": [
        0
      ],
      "name": "Hana Albulaihe"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohammed H. Alanazy"
    },
    {
      "affs": [
        0
      ],
      "name": "Meshal M. Alfallaj"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2286zdhwb77vd.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1958666",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670914/?tool=EBI",
  "id": "2286zdhwb77vd",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13670914",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Peripheral Neuropathies and Disorders"
    ]
  ],
  "openalex": "W7215036259",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670914/pdf/?tool=EBI",
  "pmcid": "PMC13670914",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2286zdhwb77vd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13670914",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13670914"
    },
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1958666",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1958666/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Peripheral Neuropathies and Disorders",
      "subfield": "neurology"
    }
  ],
  "title": "Diagnostic spectrum and clinical outcomes of chronic inflammatory demyelinating polyneuropathy: a multicenter cohort",
  "title_text": "Diagnostic spectrum and clinical outcomes of chronic inflammatory demyelinating polyneuropathy: a multicenter cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:16Z",
  "url": "https://research.draconitic.com/paper/2286zdhwb77vd",
  "venue": "Frontiers in neurology",
  "versions": []
}