{
  "abstract": "Aims/introduction\n\nDifferentiating chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) from conduction-slowing diabetic sensorimotor polyneuropathy (DSPN) is clinically challenging due to overlapping electrophysiological findings and frequent lack of responsiveness in nerve conduction studies (NCS). This study aimed to evaluate the role of high-resolution nerve ultrasound in distinguishing CIDP from conduction-slowing DSPN.Materials and methods\n\nWe retrospectively enrolled 22 CIDP and 24 conduction-slowing DSPN patients. All underwent comprehensive NCS and high-resolution nerve ultrasound. Cross-sectional areas (CSA) of multiple peripheral nerves were measured, and composite scores including the ultrasound pattern sum score (UPSS) were calculated. Statistical analyses, including logistic regression and receiver operating characteristic (ROC) curve analysis, were performed to assess diagnostic performance.Results\n\nSignificant differences were found between CIDP and conduction-slowing DSPN in both NCS and ultrasound parameters. Patients with CIDP demonstrated greater prolongation of distal latencies of NCS and F-wave latency, reduced conduction velocities, and larger nerve cross-sectional areas compared with those with conduction-slowing DSPN. However, approximately 4.5%-54.5% of patients with CIDP showed no response in NCS. A UPSS score greater than 6 achieved a sensitivity of 0.77, specifically of 0.92, and an area under the curve (AUC) of 0.89 for distinguishing CIDP from conduction-slowing DSPN.Conclusion\n\nHigh-resolution nerve ultrasound, particularly the UPSS, serves as a valuable adjunct for differentiating CIDP from conduction-slowing DSPN, especially when NCS results are inconclusive.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan.",
    "Department of Neurology, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan.",
    "Acute Intermittent Porphyria Clinical and Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.",
    "School of Medicine, College of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, Taiwan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Pei-Chen Hsieh",
      "orcid": "0000-0001-5258-5950"
    },
    {
      "affs": [
        0
      ],
      "name": "Long-Sun Ro"
    },
    {
      "affs": [
        0
      ],
      "name": "Chun-Che Chu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming-Feng Liao",
      "orcid": "0000-0001-7908-4267"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong-Shiu Chang"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Hung-Chou Kuo",
      "orcid": "0000-0001-8738-6476"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/228jam86zq2rm.bib",
  "cited_by": 0,
  "doi": "10.1111/jdi.70488",
  "fulltext_url": "https://europepmc.org/articles/PMC13750012",
  "id": "228jam86zq2rm",
  "issns": [
    "2040-1116",
    "2040-1124"
  ],
  "landing_url": "https://europepmc.org/article/MED/43006800",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Peripheral Neuropathies and Disorders"
    ]
  ],
  "openalex": "W7225735483",
  "pdf_url": "https://europepmc.org/articles/PMC13750012?pdf=render",
  "pmcid": "PMC13750012",
  "pmid": "43006800",
  "published": "2026-11-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/228jam86zq2rm.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T15:21:47Z",
      "native_id": "MED:43006800",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43006800"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Peripheral Neuropathies and Disorders",
      "subfield": "neurology"
    }
  ],
  "title": "A role for peripheral nerve ultrasound in differentiating conduction-slowing diabetic sensorimotor polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy.",
  "title_text": "A role for peripheral nerve ultrasound in differentiating conduction-slowing diabetic sensorimotor polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T03:20:44Z",
  "url": "https://research.draconitic.com/paper/228jam86zq2rm",
  "venue": "Journal of diabetes investigation",
  "versions": []
}