{
  "abstract": "This review summarizes current knowledge on the role of human cathelicidin LL-37 in the regulation of apoptosis. LL-37 can modulate programmed cell death pathways, exerting either proapoptotic or antiapoptotic effects depending on various factors, such as cell type and peptide concentration. Data on LL-37 derivatives and their involvement in apoptosis are also discussed. Understanding the molecular mechanisms underlying LL-37 regulation of apoptosis is necessary to expand the therapeutic potential of this peptide in various pathological conditions, including cancer.",
  "abstract_shown": true,
  "affiliations": [
    "Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Olga Evgenevna Voronko"
    },
    {
      "affs": [
        0
      ],
      "name": "Vitalia Sergeevna Novikova"
    },
    {
      "affs": [
        0
      ],
      "name": "Olesya Olegovna Klychkova",
      "orcid": "0009-0000-1308-4942"
    },
    {
      "affs": [
        0
      ],
      "name": "Margarita Pavlovna Markina"
    },
    {
      "affs": [
        0
      ],
      "name": "Arthur Anatolievich Lee",
      "orcid": "0009-0001-3341-4248"
    },
    {
      "affs": [
        0
      ],
      "name": "Dmitry Alexandrovich Kashirskikh",
      "orcid": "0000-0002-0748-9238"
    },
    {
      "affs": [
        0
      ],
      "name": "Victoria Alexandrovna Khotina",
      "orcid": "0000-0003-2096-3237"
    },
    {
      "affs": [
        0
      ],
      "name": "Vagif Ali oglu Gasanov"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/228xeyxw4ykyp.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27188351",
  "fulltext_url": null,
  "id": "228xeyxw4ykyp",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/18/8351",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2404|Antimicrobial Peptides and Activities"
    ]
  ],
  "openalex": "W7214458206",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-19",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/228xeyxw4ykyp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27188351",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/18/8351"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2404|Antimicrobial Peptides and Activities",
      "subfield": "microbiology"
    }
  ],
  "title": "Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling",
  "title_text": "Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:55Z",
  "url": "https://research.draconitic.com/paper/228xeyxw4ykyp",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}