{
  "abstract": "COVID-19 pandemic has significantly impacted global health, particularly evident in the detection of lung lesions via chest computed tomography scans. This study investigates the role of biomarkers in lung injury among COVID-19 patients and patients with idiopathic pulmonary fibrosis (IPF). This single-center prospective study included 154 hospitalized and 10 outpatient COVID-19 patients, 62 IPF patients, and 40 healthy volunteers, and evaluated biomarkers of alveolar epithelial cell dysfunction, extracellular matrix (ECM) and fibroblast dysfunction, and macrophage/monocyte activation (Galectin-3, CXCL13). Findings were further validated in an independant confirmation cohort (DisCoVeRy trial). COVID-19 patients had higher levels of biomarkers compared to healthy controls, except for SP-D. Compared to IPF patients, COVID-19 patients had significantly higher plasma levels of OPN, Galectin-3 and CXCL13 at admission. Elevated CXCL13 and Galectin-3 levels in COVID-19 were associated with greater lung injury. Multivariate logistic regression and Kaplan Meier analysis confirmed the role of CXCL13 in predicting severe lung injury (odd ratio 3.17, 95% CI 1.03–9.76) and in-hospital mortality (p = 0.04), with consistent results observed in the confirmation cohort. COVID-19 is characterized by increased ECM and macrophage activation biomarkers compared with IPF. CXCL13 may serve as a relevant biomarker for assessing lung injury and improving risk stratification at hospital admission.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 117,
  "authors": [
    {
      "name": "Nicolas Gendron"
    },
    {
      "name": "Carla Rial"
    },
    {
      "name": "Clément Massonnaud"
    },
    {
      "name": "An Nguyen"
    },
    {
      "name": "Aurélien Philippe"
    },
    {
      "name": "Katharina Rus"
    },
    {
      "name": "Hilario Nunes"
    },
    {
      "name": "Olivier Sanchez"
    },
    {
      "name": "Jean-Luc Diehl"
    },
    {
      "name": "Nathan Peiffer-Smadja"
    },
    {
      "name": "Maya Hites"
    },
    {
      "name": "Jeanne Rancic"
    },
    {
      "name": "Yazdan Yazdanpanah"
    },
    {
      "name": "France Mentré"
    },
    {
      "name": "Florence Ader"
    },
    {
      "name": "Dominique Israel-Biet"
    },
    {
      "name": "Olivier Espitia"
    },
    {
      "name": "David Smadja"
    },
    {
      "name": "Sandrine Couffin-Cadièrgues"
    },
    {
      "name": "Hélène Esperou"
    },
    {
      "name": "Bernd Lamprecht"
    },
    {
      "name": "Michael Joannidis"
    },
    {
      "name": "Alexander Egle"
    },
    {
      "name": "Richard Greil"
    },
    {
      "name": "Antoine Altdorfer"
    },
    {
      "name": "Vincent Fraipont"
    },
    {
      "name": "Leila Belkhir"
    },
    {
      "name": "David Bougon"
    },
    {
      "name": "Félix Djossou"
    },
    {
      "name": "Loïc Epelboin"
    },
    {
      "name": "Jean Dellamonica"
    },
    {
      "name": "Charles-Hugo Marquette"
    },
    {
      "name": "Claire Andrejak"
    },
    {
      "name": "Yoann Zerbib"
    },
    {
      "name": "Catherine Chirouze"
    },
    {
      "name": "Alexandre Boyer"
    },
    {
      "name": "Charles Cazanave"
    },
    {
      "name": "Didier Gruson"
    },
    {
      "name": "Denis Malvy"
    },
    {
      "name": "Pascal Andreu"
    },
    {
      "name": "Jean-Pierre Quenot"
    },
    {
      "name": "Nicolas Terzi"
    },
    {
      "name": "Karine Faure"
    },
    {
      "name": "Cyrille Chabartier"
    },
    {
      "name": "Vincent Le Moing"
    },
    {
      "name": "Kada Klouche"
    },
    {
      "name": "Tristan Ferry"
    },
    {
      "name": "Florent Valour"
    },
    {
      "name": "Benjamin Gaborit"
    },
    {
      "name": "Emmanuel Canet"
    },
    {
      "name": "Paul Le Turnier"
    },
    {
      "name": "David Boutoille"
    },
    {
      "name": "Fabrice Bani-Sadr"
    },
    {
      "name": "François Benezit"
    },
    {
      "name": "Matthieu Revest"
    },
    {
      "name": "Claire Cameli"
    },
    {
      "name": "Amandine Caro"
    },
    {
      "name": "Marie-Julie Ngo Um Tegue"
    },
    {
      "name": "Yves Le Tulzo"
    },
    {
      "name": "Bruno Laviolle"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/22arx0e1s1drh.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-55451-7",
  "fulltext_url": null,
  "id": "22arx0e1s1drh",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://univ-rennes.hal.science/hal-05679214v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "2.sdv.mhep.mi"
    ],
    [
      "openalex",
      "2725|COVID-19 Clinical Research Studies"
    ]
  ],
  "openalex": "W7165838135",
  "pdf_url": "https://univ-rennes.hal.science/hal-05679214/document",
  "pmcid": null,
  "pmid": "42350449",
  "published": "2026-06-25",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/22arx0e1s1drh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:01Z",
      "native_id": "hal-05679214",
      "source": "hal",
      "url": "https://univ-rennes.hal.science/hal-05679214v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.mhep.mi",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Plasma CXCL13 and fibrosis biomarkers in COVID-19 compared with idiopathic pulmonary fibrosis",
  "title_text": "Plasma CXCL13 and fibrosis biomarkers in COVID-19 compared with idiopathic pulmonary fibrosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:01Z",
  "url": "https://research.draconitic.com/paper/22arx0e1s1drh",
  "venue": "Scientific Reports",
  "versions": []
}