{
  "abstract": "Dubin-Johnson syndrome (DJS) results from ABCC2/MRP2 mutations causing impaired biliary transport. MRP2 also mediates hepatic elimination of chemotherapeutic agents, yet no data exist on anthracycline-based chemotherapy in adult DJS patients. We report a 26-year-old male with advanced-stage classic Hodgkin lymphoma and DJS harboring a novel homozygous ABCC2 variant (c.2291G>A, p.Gly764Asp). After a pembrolizumab prephase, full-dose BrECADD was administered, and samples were taken for therapeutic drug monitoring (TDM), which demonstrated normal etoposide and doxorubicin pharmacokinetics. Complete metabolic remission was achieved without significant toxicity. This case demonstrates that TDM-guided, full-dose anthracycline-based chemotherapy is feasible in DJS.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, and Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), German Hodgkin Study Group (GHSG), University of Cologne, Kerpener Str 62, 50937, Cologne, Germany. hishan.tharmaseelan@uk-koeln.de.",
    "Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, and Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), German Hodgkin Study Group (GHSG), University of Cologne, Kerpener Str 62, 50937, Cologne, Germany.",
    "Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.",
    "Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
    "Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK.",
    "Institute of Human Genetics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.",
    "Clinical Pharmacology, Department I of Pharmacology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hishan Tharmaseelan",
      "orcid": "0009-0002-5680-8714"
    },
    {
      "affs": [
        1
      ],
      "name": "Christian Peter Jaworek"
    },
    {
      "affs": [
        1
      ],
      "name": "Peter Borchmann"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Conrad-Amadeus Voltin"
    },
    {
      "affs": [
        4
      ],
      "name": "Martin Galler"
    },
    {
      "affs": [
        4
      ],
      "name": "Gareth J Veal"
    },
    {
      "affs": [
        5
      ],
      "name": "Louisa Lepkes"
    },
    {
      "affs": [
        5
      ],
      "name": "Björn Reusch"
    },
    {
      "affs": [
        5
      ],
      "name": "Clara Velmans"
    },
    {
      "affs": [
        5
      ],
      "name": "Christian Netzer"
    },
    {
      "affs": [
        6
      ],
      "name": "Wenyu Yang"
    },
    {
      "affs": [
        6
      ],
      "name": "Uwe Fuhr"
    },
    {
      "affs": [
        4
      ],
      "name": "Shelby Barnett"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/22eycjc8pj76z.bib",
  "cited_by": 0,
  "doi": "10.1007/s00280-026-04975-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13694284",
  "id": "22eycjc8pj76z",
  "issns": [
    "0344-5704",
    "1432-0843"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909633",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Drug Transport and Resistance Mechanisms"
    ]
  ],
  "openalex": "W7223327873",
  "pdf_url": "https://europepmc.org/articles/PMC13694284?pdf=render",
  "pmcid": "PMC13694284",
  "pmid": "42909633",
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/22eycjc8pj76z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909633",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909633"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Drug Transport and Resistance Mechanisms",
      "subfield": "oncology"
    }
  ],
  "title": "Successful treatment with BrECADD in a patient with Dubin-Johnson syndrome and classic Hodgkin lymphoma: a case report.",
  "title_text": "Successful treatment with BrECADD in a patient with Dubin-Johnson syndrome and classic Hodgkin lymphoma: a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/22eycjc8pj76z",
  "venue": "Cancer chemotherapy and pharmacology",
  "versions": []
}