{
  "abstract": "Background\n\nHigh-intensity statins are the cornerstone of post-ACS management. Real-world data frequently indicate suboptimal adherence and low attainment of guideline-recommended low-density lipoprotein cholesterol (LDL-C) targets.Objective\n\nThis study aimed to evaluate the early efficacy of oral lipid-lowering therapy in achieving LDL-C targets following ACS in a recent cohort of Indian patients.Methods\n\nThis single-center prospective observational study enrolled 511 statin-naive ACS patients. High-intensity statin monotherapy (atorvastatin 80 mg daily or rosuvastatin 40 mg daily) was initiated following diagnosis. Lipid profile, including total cholesterol, triglycerides, HDL-C, LDL-C, and VLDL-C, were assessed at baseline, Day 7, Day 14, and Day 28. Primary endpoints included the proportion of patients achieving LDL-C goals at Day 28.Results\n\n50.5% of patients achieved the 2019 ESC/EAS LDL-C target (<55 mg/dL) at day 28. Similarly, 68.9% achieved the 2018 ACC/AHA target (<70 mg/dL), and 44.6% achieved the 2020 Lipid Association of India (LAI) target (<50 mg/dL) at day 28. The mean LDL-C reduced from 73.43 ± 13.99 mg/dL at Day 0 to 61.26 ± 27.00 mg/dL at Day 28, corresponding to a 16.6% reduction from baseline. On multivariate analysis, baseline LDL-C, type 2 diabetes mellitus and multivessel coronary disease were found to be independent negative predictors for achieving LDL-C goal <50 mg/dL at day 28.Conclusion\n\nLDL-C target attainment following ACS remains suboptimal despite high-intensity statin therapy, highlighting the need for earlier and more intensive lipid-lowering strategies in high-risk Indian patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, King George's Medical University, Lucknow, 226003, Uttar Pradesh, India.",
    "Department of Pathology, King George's Medical University, Lucknow, 226003, Uttar Pradesh, India.",
    "Department of Cardiology, Indraprastha Apollo Hospital, New Delhi, 110076, India."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ambresh Kumar Gautam"
    },
    {
      "affs": [
        0
      ],
      "name": "Sudesh Prajapathi"
    },
    {
      "affs": [
        0
      ],
      "name": "Abhishek Singh"
    },
    {
      "affs": [
        0
      ],
      "name": "Akshyaya Pradhan"
    },
    {
      "affs": [
        1
      ],
      "name": "Wahid Ali"
    },
    {
      "affs": [
        0
      ],
      "name": "Ayush Shukla"
    },
    {
      "affs": [
        0
      ],
      "name": "Monika Bhandari"
    },
    {
      "affs": [
        0
      ],
      "name": "Akhil Sharma"
    },
    {
      "affs": [
        0
      ],
      "name": "Pravesh Vishwakarma"
    },
    {
      "affs": [
        0
      ],
      "name": "Gaurav Chaudhary"
    },
    {
      "affs": [
        0
      ],
      "name": "Sharad Chandra"
    },
    {
      "affs": [
        0
      ],
      "name": "Rishi Sethi"
    },
    {
      "affs": [
        0
      ],
      "name": "Sudhanshu Dwivedi"
    },
    {
      "affs": [
        2
      ],
      "name": "Raman Puri"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/22jqhckjd08jx.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ahjo.2026.100939",
  "fulltext_url": "https://europepmc.org/articles/PMC13677417",
  "id": "22jqhckjd08jx",
  "issns": [
    "2666-6022"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898193",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7220664543",
  "pdf_url": "https://europepmc.org/articles/PMC13677417?pdf=render",
  "pmcid": "PMC13677417",
  "pmid": "42898193",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/22jqhckjd08jx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898193",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898193"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "Early efficacy of oral lipid lowering therapy in achieving LDL-C targets following acute coronary syndrome: A real-world observational study.",
  "title_text": "Early efficacy of oral lipid lowering therapy in achieving LDL-C targets following acute coronary syndrome: A real-world observational study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/22jqhckjd08jx",
  "venue": "American heart journal plus : cardiology research and practice",
  "versions": []
}