{
  "abstract": "BACKGROUND: Heart failure (HF) is characterized by recurrent clinical deterioration, and multidimensional frailty (i.e., functional status, nutritional status, sarcopenia-related phenotypes, and cognitive impairment) is a key determinant of prognosis. We explored longitudinal changes in these multidimensional domains across recurrent hospitalizations for HF. METHODS AND RESULTS: This single-center retrospective cohort study analyzed 337 patients initially hospitalized for HF between 2016 and 2024 who subsequently experienced ≥1 rehospitalization (total 780 admissions). Longitudinal changes across repeated hospitalizations were evaluated using age- and sex-adjusted linear mixed-effects models. The median age was 83 years, and 47.2% were women. Across repeated hospitalizations, frailty and functional status worsened (Clinical Frailty Scale, β=0.40, P<0.001; Barthel Index, β=-4.21, P<0.001; Short Physical Performance Battery score, β=-0.56, P=0.043). Gait speed also declined, although this trend did not reach statistical significance (β=-0.03, P=0.089). Nutritional status deteriorated (Controlling Nutritional Status score, β=0.56, P<0.001; Geriatric Nutritional Risk Index, β=-2.37, P<0.001). Sarcopenia-related indices deteriorated (appendicular skeletal muscle index, β=-2.79, P=0.006; grip strength, β=-4.64%, P<0.001). Cognitive function assessed by the Mini-Mental State Examination showed no significant longitudinal change (β=0.11, P=0.501). CONCLUSIONS: Many domains of frailty deteriorated across recurrent hospitalizations for HF, suggesting cumulative frailty progression.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Yuta Ozaki"
    },
    {
      "name": "Yusuke Uemura"
    },
    {
      "name": "Shigefumi Honda"
    },
    {
      "name": "Toru Kondo"
    },
    {
      "name": "Shingo Kazama"
    },
    {
      "name": "Kenji Takemoto"
    },
    {
      "name": "Masato Watarai"
    },
    {
      "name": "Toyoaki Murohara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/22rp0p7bv5bg7.bib",
  "cited_by": 1,
  "doi": "10.1253/circj.cj-26-0186",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0186/_article",
  "id": "22rp0p7bv5bg7",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0186/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2705|Heart Failure Treatment and Management"
    ]
  ],
  "openalex": "W7162317959",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0186/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/22rp0p7bv5bg7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-26-0186",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0186/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Trajectory of Multidimensional Frailty Across Recurrent Heart Failure Hospitalizations ― A Single-Center Longitudinal Cohort Study ―",
  "title_text": "Trajectory of Multidimensional Frailty Across Recurrent Heart Failure Hospitalizations ― A Single-Center Longitudinal Cohort Study ―",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/22rp0p7bv5bg7",
  "venue": "Circulation Journal",
  "versions": []
}