{
  "abstract": "β‑arrestin serves as a core functional effector governing signal transduction of G protein-coupled receptors (GPCRs), exerting dual roles as a signal terminator and molecular scaffold. However, the molecular mechanism underlying how β-arrestin responds to diverse GPCRs and interacts with hundreds of effector proteins to mediate a broad spectrum of physiological functions remains poorly understood. A landmark original study recently published in Nature overturned the conventional view of β‑arrestin as a static scaffold protein. Endogenously expressed β‑arrestin undergoes liquid-liquid phase separation (LLPS) to form highly dynamic biomolecular condensates, which orchestrate compartmentalized assembly and fine-tuning of GPCR signaling complexes. This work establishes a novel paradigm centered on β‑arrestin condensates for GPCR signal regulation and reshapes the molecular framework of hierarchically organized intracellular signaling networks.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Life Sciences and Medicine, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "WANG Yuan-Xia"
    },
    {
      "affs": [
        0
      ],
      "name": "SUN De-Meng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/22vkhg1vatb4c.bib",
  "cited_by": 0,
  "doi": "10.3724/j.pibb.2026.0337",
  "fulltext_url": "https://www.pibb.ac.cn/pibbcn/article/abstract/20260337",
  "id": "22vkhg1vatb4c",
  "issns": [
    "1000-3282"
  ],
  "landing_url": "https://doi.org/10.3724/j.pibb.2026.0337",
  "language": "zh",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QD415-436"
    ],
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "1312|Receptor Mechanisms and Signaling"
    ]
  ],
  "openalex": "W7224103814",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Editorial Office of Progress in Biochemistry and Biophysics",
  "ris": "https://research.draconitic.com/paper/22vkhg1vatb4c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:29Z",
      "native_id": "56d775cf315e49a28c4eac733f91c62b",
      "source": "doaj",
      "url": "https://doi.org/10.3724/j.pibb.2026.0337"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Receptor Mechanisms and Signaling",
      "subfield": "molecular-biology"
    }
  ],
  "title": "β-Arrestin Condensate: a New Paradigm for Spatiotemporal Regulation of GPCR Signaling",
  "title_text": "β-Arrestin Condensate: a New Paradigm for Spatiotemporal Regulation of GPCR Signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:29Z",
  "url": "https://research.draconitic.com/paper/22vkhg1vatb4c",
  "venue": "Shengwu huaxue yu shengwu wuli jinzhan",
  "versions": []
}