{
  "abstract": "Background: Visceral adipose tissue (VAT) may causally contribute to cardiovascular disease (CVD); however, evidence in Latin America is limited. Here, we evaluated the association between estimated VAT (eVAT) and incident CVD among individuals without diabetes and estimated its population-attributable fraction (PAF) using data from the Cohorts Consortium of Latin America and the Caribbean (CC-LAC). Methods: We pooled data from 15 prospective cohorts across 7 countries (n = 23,097; 62% women [n = 14,383], median age 51 years). Baseline eVAT (in grams [g]) was estimated using the Metabolic Score for Visceral Fat (METS-VF) index, incorporating age, sex, an insulin resistance index, and waist-to-height ratio. The primary outcome was incident CVD events, including fatal and non-fatal outcomes. Cause-specific Cox proportional hazards models estimated adjusted hazard ratios (aHR). PAF estimates used scenario-based eVAT quartile reductions. Findings: Over a median follow-up of 4 years (113,622 person-years), 436 participants (1.9%) experienced an incident CVD event (174 fatal; 262 non-fatal). Uniformly age- and sex-standardized incidence rates were 3.8 (95% CI: 3.5-4.2) per 1000 person-years. Each 100 g increase in eVAT was associated with a 4% higher CVD hazard (aHR 1.04, 1.03-1.06). Compared with Q1 (<735 g), those in Q3 (1069-1441 g) and Q4 (≥1441 g) had a higher CVD hazard (Q3 aHR: 1.78 [1.28-2.49]; Q4 aHR: 2.03 [1.48-2.79]; p-for-trend <0.001). Associations were stronger for non-fatal events. In PAF estimates, shifting individuals from Q4 to lower quartiles could prevent 8.8% (2.8%-14.7%) of CVD events over 10 years. Interpretation: Higher eVAT was associated with increased CVD risk in Latin America, supporting the view that modest VAT reductions could decrease regional CVD burden. Funding: CC-LAC was funded by the Wellcome Trust.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 102,
  "authors": [
    {
      "name": "Mario Cesar Torres-Chavez"
    },
    {
      "name": "Jesus Ernesto Martinez-Luna"
    },
    {
      "name": "Maria Fernanda Suarez-Velazquez"
    },
    {
      "name": "Carlos Alberto Fermin-Martinez"
    },
    {
      "name": "Rodrigo M. Carrillo-Larco"
    },
    {
      "name": "Dalia Stern"
    },
    {
      "name": "Ian R. Hambleton"
    },
    {
      "name": "Paulo Lotufo"
    },
    {
      "name": "Mariachiara Di Cesare"
    },
    {
      "name": "Anselm Hennis"
    },
    {
      "name": "Catterina Ferreccio"
    },
    {
      "name": "Vilma Irazola"
    },
    {
      "name": "Pablo Perel"
    },
    {
      "name": "Edward W. Gregg"
    },
    {
      "name": "J Jaime Miranda"
    },
    {
      "name": "Majid Ezzati"
    },
    {
      "name": "Goodarz Danaei"
    },
    {
      "name": "Omar Yaxmehen Bello-Chavolla"
    },
    {
      "name": "Neftali Eduardo Antonio-Villa"
    },
    {
      "name": "Adolfo Rubinstein"
    },
    {
      "name": "Aaron Salinas-Rodriguez"
    },
    {
      "name": "Adrian Cortes-Valencia"
    },
    {
      "name": "Alexandre C. Pereira"
    },
    {
      "name": "Alvaro C.C. Maciel"
    },
    {
      "name": "Alvaro Ruiz-Morales"
    },
    {
      "name": "Andrea Huidobro"
    },
    {
      "name": "Andrea R.V.R. Horimoto"
    },
    {
      "name": "Antonio Bernabe-Ortiz"
    },
    {
      "name": "Berenice Rivera-Paredez"
    },
    {
      "name": "Betty S. Manrique-Espinoza"
    },
    {
      "name": "Blanca H. Ceballos"
    },
    {
      "name": "Carla D.O. Bernardo"
    },
    {
      "name": "Carlos A. Aguilar-Salinas"
    },
    {
      "name": "Cassiano R. Rech"
    },
    {
      "name": "Cecilia Baccino"
    },
    {
      "name": "Paula Parnizari"
    },
    {
      "name": "Claudia Bambs"
    },
    {
      "name": "Clicerio Gonzalez-Villalpando"
    },
    {
      "name": "David A. Gonzalez-Chica"
    },
    {
      "name": "Donaji Gomez-Velasco"
    },
    {
      "name": "Elard Koch"
    },
    {
      "name": "Eleonora D’orsi"
    },
    {
      "name": "Fernando L. Herkenhoff"
    },
    {
      "name": "Fiorella Tartaglione"
    },
    {
      "name": "Flavio D. Fuchs"
    },
    {
      "name": "Gilbert Brenes-Camacho"
    },
    {
      "name": "Gladys E. Maestre"
    },
    {
      "name": "Gloria Beckles"
    },
    {
      "name": "Gonzalo Grazioli"
    },
    {
      "name": "Horacio A. Carbajal"
    },
    {
      "name": "Jackie A. Cooper"
    },
    {
      "name": "Jesus D. Melgarejo"
    },
    {
      "name": "Joao Luiz Bastos"
    },
    {
      "name": "Jorge Salmeron"
    },
    {
      "name": "Jorge Tartaglione"
    },
    {
      "name": "Jose G. Boggia"
    },
    {
      "name": "Jose G. Mill"
    },
    {
      "name": "Juan E. Blumel"
    },
    {
      "name": "Karen G. Peres"
    },
    {
      "name": "Karen Oppermann"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/23ap3mpt28a82.bib",
  "cited_by": 0,
  "doi": "10.1016/j.lana.2026.101603",
  "fulltext_url": null,
  "id": "23ap3mpt28a82",
  "issns": [
    "2667-193X"
  ],
  "landing_url": "https://hal.science/hal-05791925v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "hal",
      "0.sdv"
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      "hal",
      "1.sdv.spee"
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    [
      "openalex",
      "2705|Cardiovascular Disease and Adiposity"
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  "openalex": "W7204758729",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-11",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/23ap3mpt28a82.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:53Z",
      "native_id": "hal-05791925",
      "source": "hal",
      "url": "https://hal.science/hal-05791925v1"
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  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
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    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
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  ],
  "title": "Visceral adipose tissue and incident cardiovascular disease among individuals without diabetes: an analysis of 15 prospective cohorts from 7 countries in Latin America",
  "title_text": "Visceral adipose tissue and incident cardiovascular disease among individuals without diabetes: an analysis of 15 prospective cohorts from 7 countries in Latin America",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:53Z",
  "url": "https://research.draconitic.com/paper/23ap3mpt28a82",
  "venue": "The Lancet Regional Health - Americas",
  "versions": []
}