{
  "abstract": "Objective\n\nTo analyze the time series and trend of the syphilis in pregnancy detection rate over nine years and the variations in clinical and epidemiological characteristics across four periods according to relevant public health events in Campo Grande, Mato Grosso do Sul.Methods\n\nTime series study with descriptive analysis by periods, using data from the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação, SINAN) and the Live Birth Information System (Sistema Nacional de Nascidos Vivos, SINASC). Segmented linear regression was used to analyze the temporal trend of the syphilis in pregnancy detection rate, and the Kruskal-Wallis test was employed to analyze clinical and epidemiological variables across the evaluated periods: penicillin shortage (2015-2016); supply normalization and pre-pandemic period (2017-2019); pandemic (2020-2021); and post-COVID-19 pandemic (2022-2023).Results\n\nA total of 2,802 cases were analyzed. An increase of 170.4% in the detection rate was observed, with a rising trend until 2018 (annual percentage change, APC 31.18%; 95% confidence interval, 95%CI 4.79; 118.80; p-value 0.017) and subsequent stabilization (APC 1.16%; 95%CI -27.24; 15.83; p-value 0.936). Regarding clinical-epidemiological characteristics, there was an increase in the frequency of latent phase, reactive treponemal tests, adequate treatment, and maternal education, and a reduction in partner treatment. During 2017-2019, there was a reduction in the use of non-treponemal tests; in 2020-2021, a decrease in Brown (Brazilian mixed race)/Black/Asian/Indigenous women; and in 2022-2023, an increase in prenatal care visits and late diagnoses.Conclusion\n\nThe syphilis in pregnancy detection rate increased until 2018 and remained stable thereafter. Changes in clinical and epidemiological characteristics reflect variations in the care context, with advances in prenatal care, but persistence of weaknesses in the timely diagnosis and treatment of partners.",
  "abstract_shown": true,
  "affiliations": [
    "Universidade Federal de Mato Grosso do Sul Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias Campo GrandeMS Brazil Universidade Federal de Mato Grosso do Sul, Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias, Campo Grande, MS, Brazil.",
    "Universidade Federal de Mato Grosso do Sul Faculdade de Medicina Campo GrandeMS Brazil Universidade Federal de Mato Grosso do Sul, Faculdade de Medicina, Campo Grande, MS, Brazil.",
    "Universidade Federal de Mato Grosso do Sul Instituto Integrado de Saúde Campo GrandeMS Brazil Universidade Federal de Mato Grosso do Sul, Instituto Integrado de Saúde, Campo Grande, MS, Brazil.",
    "Universidade Federal do Vale do São Francisco Faculdade de Medicina PetrolinaPE Brazil Universidade Federal do Vale do São Francisco, Faculdade de Medicina, Petrolina, PE, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Caroliny Oviedo Fernandes Reis",
      "orcid": "0000-0003-2810-6408"
    },
    {
      "affs": [
        0
      ],
      "name": "Luciana Aparecida da Cunha Borges",
      "orcid": "0000-0002-4058-0885"
    },
    {
      "affs": [
        1
      ],
      "name": "Cláudia Du Bocage Santos-Pinto",
      "orcid": "0000-0002-5478-4977"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana Lúcia Lyrio de Oliveira",
      "orcid": "0000-0002-7535-6816"
    },
    {
      "affs": [
        2
      ],
      "name": "Daniele Soares-Marangoni",
      "orcid": "0000-0002-5354-5456"
    },
    {
      "affs": [
        3
      ],
      "name": "Carlos Dornels Souza Freire",
      "orcid": "0000-0001-7995-1893"
    },
    {
      "affs": [
        0
      ],
      "name": "Everton Falcão de Oliveira",
      "orcid": "0000-0002-0074-5278"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/23rhejzd15kba.bib",
  "cited_by": 0,
  "doi": "10.1590/s2237-96222026v35e20250940.en",
  "fulltext_url": "https://europepmc.org/articles/PMC13686406",
  "id": "23rhejzd15kba",
  "issns": [
    "1679-4974",
    "2237-9622"
  ],
  "landing_url": "https://europepmc.org/article/MED/42922787",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Syphilis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7171442191",
  "pdf_url": "https://europepmc.org/articles/PMC13686406?pdf=render",
  "pmcid": "PMC13686406",
  "pmid": "42922787",
  "published": "2026-07-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/23rhejzd15kba.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42922787",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42922787"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Syphilis Diagnosis and Treatment",
      "subfield": "physiology"
    }
  ],
  "title": "Syphilis in pregnancy detection rate: time series study associated with descriptive analysis by periods, Campo Grande, 2015-2023.",
  "title_text": "Syphilis in pregnancy detection rate: time series study associated with descriptive analysis by periods, Campo Grande, 2015-2023.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/23rhejzd15kba",
  "venue": "Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil",
  "versions": []
}