{
  "abstract": "Extracellular vesicles (EVs) are essential for intercellular communication and significantly influence neuroimmune responses after intracerebral haemorrhage (ICH). This study elucidates the immune mechanisms underlying secondary brain injury following ICH by identifying microglia‐derived migrasomes. By integrating immune cell clustering analysis from single‐cell RNA sequencing (scRNA‐seq) with Mendelian randomization, we identified five key genes associated with ICH. Further experiments revealed that C1qc accumulates around hematomas, worsening blood‒brain barrier (BBB) disruption through migrasome‐mediated pathways. Our results showed that microglial migrasomes transport C1qc to induce pyroptosis in vascular endothelial cells, thereby compromising BBB integrity. Genetic ablation of C1qc substantially attenuated this BBB damaging effect, C1qc‐deficient migrasomes exhibited protective properties. Our findings, for the first time, reveal the mechanistic role of C1qc and migrasomes in ICH pathogenesis and establish microglia‐derived migrasomes as promising therapeutic targets, providing novel avenues to improve neurologic outcomes after ICH.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China",
    "Department of Human Anatomy, School of Basic Medical Sciences Zhengzhou University Zhengzhou Henan China",
    "Department of Medical Research & Education Shuang Ho Hospital, Taipei Medical University New Taipei City Taiwan",
    "School of Basic Medical Sciences Zhengzhou University Zhengzhou Henan China",
    "The First Clinical Medical School, Department of Geriatrics Hubei University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan Hubei China",
    "Department of Medical Laboratory, Jiujiang Clinical Precision Medicine Research Center Affiliated Hospital of Jiujiang University Jiujiang Jiangxi China",
    "Department of Neurology, Jiujiang Clinical Precision Medicine Research Center Affiliated Hospital of Jiujiang University Jiujiang Jiangxi China",
    "Aging Decoding and Regeneration InstituteSchool of Basic Medical SciencesZhengzhou UniversityZhengzhou Henan China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mengyuan Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhihua Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Dengpan Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Fang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengzhao Feng"
    },
    {
      "affs": [
        2
      ],
      "name": "Chi‐Tai Yeh"
    },
    {
      "affs": [
        0
      ],
      "name": "Tingting Zhai"
    },
    {
      "affs": [
        0
      ],
      "name": "Menghan Deng"
    },
    {
      "affs": [
        1
      ],
      "name": "Yanyan Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Junyang Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuemei Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Yating Wang"
    },
    {
      "affs": [
        4
      ],
      "name": "Qiong Yang"
    },
    {
      "affs": [
        5
      ],
      "name": "Moxin Wu"
    },
    {
      "affs": [
        6
      ],
      "name": "Xiaoping Yin"
    },
    {
      "affs": [
        1
      ],
      "name": "Junmin Wang"
    },
    {
      "affs": [
        7
      ],
      "name": "Jian Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Fuyou Guo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/24bttc3xygyq5.bib",
  "cited_by": 0,
  "doi": "10.1002/jev2.70377",
  "fulltext_url": "https://doi.org/10.1002/jev2.70377",
  "id": "24bttc3xygyq5",
  "issns": [
    "2001-3078"
  ],
  "landing_url": "https://doi.org/10.1002/jev2.70377",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QH573-671"
    ],
    [
      "openalex",
      "2728|Intracerebral and Subarachnoid Hemorrhage Research"
    ]
  ],
  "openalex": "W7221011639",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jev2.70377",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/24bttc3xygyq5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:10Z",
      "native_id": "783b5b46fd2144169030d31bf16bab9d",
      "source": "doaj",
      "url": "https://doi.org/10.1002/jev2.70377"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracerebral and Subarachnoid Hemorrhage Research",
      "subfield": "neurology"
    }
  ],
  "title": "C1qc Mediates Blood–Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia‐Derived Migrasomes",
  "title_text": "C1qc Mediates Blood–Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia‐Derived Migrasomes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:10Z",
  "url": "https://research.draconitic.com/paper/24bttc3xygyq5",
  "venue": "Journal of Extracellular Vesicles",
  "versions": []
}