{
  "abstract": "Lead is a ubiquitous environmental and industrial toxicant known to cause reproductive toxicity and neurotoxicity via the induction of oxidative damage and modulation of neurotransmitters. On the other hand, oleuropein and alpha-lipoic acid have independently been reported to demonstrate antioxidant and neurotransmitter modulatory activities. Here, we evaluated the protective role of oleuropein/alpha lipoic acid in lead-induced reproductive toxicity and neurotoxicity in Drosophila melanogaster. A 7-day survival analysis was carried out, and subsequently, flies were exposed to vehicle, lead acetate (20 mg/kg diet), and/or oleuropein and alpha lipoic acid (0.1 mg/kg diet) for 7 days. Oleuropein and alpha lipoic acid restored lead-induced weight loss and suppression of reduced glutathione, superoxide dismutase, and catalase activities, as well as elevated malondialdehyde contents. In addition, oleuropein and alpha lipoic acid ameliorated lead-induced increases in acetylcholinesterase and monoamine oxidase activities and reductions in acetylcholine, dopamine, and serotonin in flies. Additionally, lead-induced disruption of climbing activity, courtship and mating latencies, mating duration, copulation success rate, and emergence rate were ameliorated by oleuropein and alpha lipoic acid in D. melanogaster. Overall, oleuropein and alpha lipoic acid attenuated lead-induced reproductive toxicity and neurotoxicity in D. melanogaster. Thus, oleuropein/alpha lipoic acid is a promising candidate for further investigation against lead-induced toxicity.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anatomy, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria",
    "Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria",
    "Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State Nigeria",
    "Department of Agronomy, Osun State University, Ejigbo campus, Ejigbo, Osun State Nigeria",
    "Department of Pure and Applied Biology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State Nigeria"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ebenezer Adeola Ashamu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Favour Eyitayo Akande"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Kaosarat Ajoke Oyekan"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Rhoda Opeyemi Fakunle"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Kamilah Oluwamayokun Adigun"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Tunmise Maryanne Akhigbe"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Cecilia Adedeji Adegbola"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Blessing Monica Akindele"
    },
    {
      "affs": [
        4
      ],
      "name": "Julius Kola Oloke"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Roland Eghoghosoa Akhigbe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/258epbsrkyves.bib",
  "cited_by": 0,
  "doi": "10.1186/s40360-026-01193-1",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733115/",
  "id": "258epbsrkyves",
  "issns": [
    "2050-6511"
  ],
  "landing_url": "https://doi.org/10.1186/s40360-026-01193-1",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "lcc",
      "RA1190-1270"
    ],
    [
      "lcc",
      "RM1-950"
    ],
    [
      "openalex",
      "2307|Heavy Metal Exposure and Toxicity"
    ]
  ],
  "openalex": "W7197013972",
  "pdf_url": null,
  "pmcid": "PMC13733115",
  "pmid": "42983608",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/258epbsrkyves.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:58Z",
      "native_id": "PMC13733115",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s40360-026-01193-1"
    },
    {
      "first_seen": "2026-11-08T14:21:02Z",
      "native_id": "0068bf208c9d46aead5d527b9ded6d71",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s40360-026-01193-1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Heavy Metal Exposure and Toxicity",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Antioxidant response and neurotransmitter modulation driven by oleuropein/alpha-lipoic acid attenuates lead-induced reproductive toxicity and neurotoxicity in Drosophila melanogaster",
  "title_text": "Antioxidant response and neurotransmitter modulation driven by oleuropein/alpha-lipoic acid attenuates lead-induced reproductive toxicity and neurotoxicity in Drosophila melanogaster",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T14:21:02Z",
  "url": "https://research.draconitic.com/paper/258epbsrkyves",
  "venue": "BMC Pharmacology & Toxicology",
  "versions": []
}