{
  "abstract": "Wine lees are a phenolic-rich winery by-product whose liquid fraction remains underexploited. This study investigated the direct recovery of phenolic compounds from the liquid fraction of red wine lees (LfWL) using the non-ionic Amberlite XAD-16 resin through batch and fixed-bed adsorption, followed by sequential desorption and LC-HRMS profiling. Batch adsorption experiments were conducted at resin dosages ranging from 20 to 120 g/L. The highest adsorption yield (89.9%) was achieved at 120 g/L, whereas the highest experimental adsorption capacity (123.5 mg SAE/g) was obtained at 20 g/L. Adsorption kinetics were better described by the pseudo-second-order model, whereas the non-linear Langmuir model provided the best equilibrium fit, with a model-estimated maximum adsorption capacity of 304.34 mg SAE/g. Phenolics adsorption was favored at the natural pH of the LfWL, while the thermodynamic analysis indicated an exothermic and thermodynamically favorable process. Two different fixed-bed columns were evaluated under continuous flow conditions. The configuration with larger dimensions (LFB-200) treated an undiluted LfWL, reaching an adsorption efficiency of 36.59% with a breakthrough profile extending beyond 1400 min. Sequential elution with water followed by a 50% (v/v) ethanol/water mixture resulted in desorption yields of 88.96% and 79.54% for the small and large columns, respectively. LC-HRMS enabled the putative annotation of 20 phenolic compounds and revealed compound and class-dependent elution profiles. These results support resin adsorption as a promising route for direct phenolic recovery from liquid wine lees fractions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemical Engineering, University of Patras, 26504 Patras, Greece",
    "Department of Sustainable Agriculture, University of Patras, 30100 Agrinio, Greece",
    "Foundation for Research and Technology—Hellas, Institute of Chemical Engineering Sciences, FORTH/ICE-HT, 26504 Patras, Greece"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Antonis Vasilopoulos",
      "orcid": "0009-0005-7370-9082"
    },
    {
      "affs": [
        0
      ],
      "name": "Varvara Sygouni",
      "orcid": "0000-0002-8166-4065"
    },
    {
      "affs": [
        0
      ],
      "name": "Christina Vasiliki Lazaratou",
      "orcid": "0000-0001-8447-9124"
    },
    {
      "affs": [
        1
      ],
      "name": "Athanasia G. Tekerlekopoulou",
      "orcid": "0000-0003-3392-9054"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Dimitris V. Vayenas",
      "orcid": "0000-0003-1325-1960"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/25e9vk86mvr9h.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31213929",
  "fulltext_url": null,
  "id": "25e9vk86mvr9h",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/21/3929",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/25e9vk86mvr9h.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:24:01Z",
      "native_id": "10.3390/molecules31213929",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/21/3929"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "issn:1420-3049",
      "subfield": "general"
    }
  ],
  "title": "Red Wine Lees Valorization for Phenolic Compounds Recovery and Characterization Using Resin Adsorption",
  "title_text": "Red Wine Lees Valorization for Phenolic Compounds Recovery and Characterization Using Resin Adsorption",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:20:53Z",
  "url": "https://research.draconitic.com/paper/25e9vk86mvr9h",
  "venue": "Molecules",
  "versions": []
}