{
  "abstract": "BACKGROUND: Cognitive resilience to Alzheimer's disease (AD) can be modelled in amyloid-expressing rodents through early handling (EH). This study investigated how EH and sex affect cognition and pathology over time. METHODS: We assessed cognition (Open field, Novel object recognition test, Barnes maze) in 6- and 12-month-old APP/PS1 and WT mice (N=180, EH/Ctrl X M/F), performed biochemical and histological analyses of several brain areas to assess effects on amyloid-beta, glial cells, and other markers of pathology, and investigated how behavior correlates with pathology. RESULTS: EH improved non-spatial memory at 6 months, consistent with a reduction of hippocampal microglia density, and normalized locomotor activity at 12 months (both p<0.05). Females demonstrated similar (6 & 12 months) or better (12 months) cognition, despite greater pathology across timepoints. Correlations implicated microglial recruitment in EH-related effects, supported by morphological analysis of prefrontal regions (p<0.05). CONCLUSION: Our findings highlight the critical role of early postnatal experiences and sex in shaping resilience in the context of AD pathology.",
  "abstract_shown": true,
  "affiliations": [
    "Amsterdam University Medical Center"
  ],
  "article_type": "Confirmatory results",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "M. Carrigan"
    },
    {
      "name": "J. Sanguino-Gomez"
    },
    {
      "name": "M. Bayer-Var"
    },
    {
      "name": "O. Minko"
    },
    {
      "name": "A. Bobkova"
    },
    {
      "name": "E. Ruzicka"
    },
    {
      "name": "L. Lopez-Fedjajeva"
    },
    {
      "name": "N. Renckens"
    },
    {
      "name": "L. Givalois"
    },
    {
      "name": "P. J. Lucassen"
    },
    {
      "name": "R. Ossenkoppele"
    },
    {
      "name": "H. J. Krugers"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/260manb0yes2v.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.29.754953",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.754953v1.full",
  "id": "260manb0yes2v",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.754953v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "animal behavior and cognition"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7220430340",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.754953v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/260manb0yes2v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:05Z",
      "native_id": "10.64898/2026.09.29.754953",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.29.754953v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:animal behavior and cognition",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time",
  "title_text": "The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:05Z",
  "url": "https://research.draconitic.com/paper/260manb0yes2v",
  "venue": "bioRxiv",
  "versions": []
}