{
  "abstract": "Objective: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are standard targeted therapies for EGFR-mutant non-small cell lung cancer (NSCLC), but clinically documented EGFR-TKI-associated colitis remains incompletely characterized. We aimed to describe its clinical, radiographic, endoscopic, histopathologic, management, and exploratory survival features.\n\nMethods: We conducted a single-center retrospective case-control analysis nested within an institutional cohort of 3,285 patients with NSCLC treated with EGFR-TKIs between January 2018 and July 2025. The analysis included 43 patients with documented radiographic and/or endoscopic colitis and 223 selected asymptomatic controls. Clinical, imaging, colonoscopic, histopathologic, treatment, and survival data were reviewed. Ever-smoking was examined in an exploratory univariable logistic analysis. Drug-specific EGFR-TKI odds were not estimated because a common time-aligned exposure definition for cases and controls could not be reconstructed, and overall survival was examined exploratorily.\n\nResults: Clinically documented EGFR-TKI-associated colitis occurred in 43/3,285 treated patients (1.3%). Ever-smoking was more frequent among cases than selected controls (39.5% vs. 20.2%; univariable odds ratio = 2.586, 95% confidence interval: 1.293–5.173, P = 0.007). Drug-specific odds were not estimated because a common time-aligned exposure definition could not be reconstructed. Median symptom onset was 3 months. Diarrhea occurred in 40/43 patients (93.0%); three patients had grade 0 diarrhea. Among 39 patients undergoing colonoscopy, 14 had normal-appearing mucosa; 11 of these patients underwent biopsy and showed histologic inflammation. Of 35 classifiable biopsies, 10 (28.6%) showed a microscopic pattern, 14 (40.0%) an inflammatory/IBD-like pattern, and 11 (31.4%) an ischemic-like pattern. In exploratory survival analysis, no statistically significant association between documented colitis and overall survival was detected (log-rank P = 0.538; adjusted HR = 1.184, 95% CI: 0.782–1.793, P = 0.426).\n\nConclusion: Clinically documented EGFR-TKI-associated colitis showed heterogeneous radiographic, endoscopic, and histopathologic patterns. Normal-appearing mucosa did not exclude histologic inflammation in biopsied patients. The 1.3% value represents documented cases in this institutional cohort rather than population incidence. The recorded smoking difference, severity-stratified findings, treatment outcomes, and survival estimates should be interpreted as exploratory; no drug-specific colitis association is inferred.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China",
    "Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China",
    "Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shujun Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chen Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Pufang Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Ya Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Hefeng Zhan"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiajing Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/26dq8sqxzrb7y.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1935622",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696202/",
  "id": "26dq8sqxzrb7y",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://doi.org/10.3389/fphar.2026.1935622",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2740|Lung Cancer Treatments and Mutations"
    ]
  ],
  "openalex": "W7221461050",
  "pdf_url": "https://europepmc.org/articles/PMC13696202?pdf=render",
  "pmcid": "PMC13696202",
  "pmid": "42935484",
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/26dq8sqxzrb7y.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "PMC13696202",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fphar.2026.1935622"
    },
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1935622",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1935622/full"
    },
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42935484",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42935484"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1663-9812",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "EGFR-TKI-associated colitis in non-small cell lung cancer: a retrospective characterization of clinical, radiographic, endoscopic, and histopathologic features",
  "title_text": "EGFR-TKI-associated colitis in non-small cell lung cancer: a retrospective characterization of clinical, radiographic, endoscopic, and histopathologic features",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:35Z",
  "url": "https://research.draconitic.com/paper/26dq8sqxzrb7y",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}