{
  "abstract": "Background/Objectives: This study evaluates whether saline infiltration during coaxial needle withdrawal reduces the incidence of pneumothorax (PTX) in CT-guided lung biopsies, potentially enhancing procedural safety. Methods: A retrospective analysis of 200 consecutive CT-guided core needle biopsies (18G) was conducted using our hospital's Radiology Department database. All procedures were performed between February 2022 and December 2024 by a single operator with 20 years of experience. Patients were divided into two groups: Group A (100 patients), receiving 10 mL of 0.9% saline solution during coaxial needle withdrawal, and Group B (100 patients), in whom no saline was infiltrated. Descriptive and inferential statistical analyses were used to assess the relationship between saline infiltration and the incidence of PTX. Results: PTX occurred in 24% of Group B patients versus 7% in Group A (p = 0.001). Multivariate analysis identified saline infiltration as a significant protective factor, even in high-risk patients (e.g., those with emphysema or in lateral decubitus). The odds ratio (OR = 0.18; 95% CI: 0.07-0.48) indicates that saline infiltration significantly reduces the risk of PTX. Conclusions: Infiltration of 10 mL of saline during coaxial needle withdrawal significantly reduces the incidence of PTX in CT-guided lung biopsies, offering a simple and effective strategy to enhance patient safety.",
  "abstract_shown": true,
  "affiliations": [
    "University Hospital of Parma, Via Gramsci 14, 43126 Parma, PR, Italy.",
    "Areteion Hospital, National and Kapodistrian University of Athens, 76, Vas. Sophias Ave, 11528 Athens, Greece."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Giulia Viviano",
      "orcid": "0009-0008-2974-4958"
    },
    {
      "affs": [
        0
      ],
      "name": "Ganyat Adenike Ralitsa Adebanjo",
      "orcid": "0000-0001-8850-3072"
    },
    {
      "affs": [
        0
      ],
      "name": "Giorgio Concari"
    },
    {
      "affs": [
        0
      ],
      "name": "Chiara Martini",
      "orcid": "0000-0002-0877-4954"
    },
    {
      "affs": [
        0
      ],
      "name": "Giuseppe Pedrazzi",
      "orcid": "0000-0002-5971-2040"
    },
    {
      "affs": [
        1
      ],
      "name": "Miltos Krokidis",
      "orcid": "0000-0002-2191-240X"
    },
    {
      "affs": [
        0
      ],
      "name": "Massimo De Filippo",
      "orcid": "0000-0002-3531-8858"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/26h4gxj42n8kr.bib",
  "cited_by": 0,
  "doi": "10.3390/diagnostics16193080",
  "fulltext_url": "https://europepmc.org/articles/PMC13664532",
  "id": "26h4gxj42n8kr",
  "issns": [
    "2075-4418"
  ],
  "landing_url": "https://europepmc.org/article/MED/42882235",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Pleural and Pulmonary Diseases"
    ]
  ],
  "openalex": "W7214055254",
  "pdf_url": "https://europepmc.org/articles/PMC13664532?pdf=render",
  "pmcid": "PMC13664532",
  "pmid": "42882235",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/26h4gxj42n8kr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42882235",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42882235"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Pleural and Pulmonary Diseases",
      "subfield": "general"
    }
  ],
  "title": "How Effective Is Saline Solution Infiltration During Coaxial Needle Withdrawal in Reducing the Incidence of Pneumothorax in CT-Guided Lung Biopsies?",
  "title_text": "How Effective Is Saline Solution Infiltration During Coaxial Needle Withdrawal in Reducing the Incidence of Pneumothorax in CT-Guided Lung Biopsies?",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/26h4gxj42n8kr",
  "venue": "Diagnostics (Basel, Switzerland)",
  "versions": []
}