{
  "abstract": "Microwave-enhanced solid phase peptide synthesis of complex, therapeutically relevant, aspartimide-prone secretin hormones was achieved under optimized conditions with economical and commercially available protected amino acids. In order to determine robust and general methods, standard Fmoc SPPS conditions, Oxyma-buffered deprotection solution, Fmoc-(Dmb)Gly-OH, Fmoc-Asp(OMpe)-OH, and combinations thereof were systematically evaluated for crude purity using LC-MS. Aspartimide formation was significantly reduced, and syntheses were completed in a single run without the need for expensive, commercially inaccessible, or diversity-limiting peptide fragments or pseudoprolines, supplying methods amenable for rapid library generation, hit-to-lead endeavors, and lead optimization.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Industrial and Molecular Pharmaceutics",
    "Institute for Drug Discovery",
    "Department of Chemistry",
    "Institute of Inflammation, Immunology, and Infectious Disease",
    "Purdue University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Brenson A. Jassim"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Kyle T. Faivre"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Severin T. Schneebeli",
      "orcid": "0000-0002-9511-9922"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/26jkvshhb1xan.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15003792/v2",
  "fulltext_url": null,
  "id": "26jkvshhb1xan",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15003792/v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Chemical Synthesis and Analysis"
    ]
  ],
  "openalex": "W7220711914",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15003792/v2",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/26jkvshhb1xan.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15003792",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15003792/v2"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Chemical Synthesis and Analysis",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Efficient Microwave-Enhanced Solid Phase Peptide Synthesis of Secretin Hormones Amenable for Rapid Library Design and Lead Optimization",
  "title_text": "Efficient Microwave-Enhanced Solid Phase Peptide Synthesis of Secretin Hormones Amenable for Rapid Library Design and Lead Optimization",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/26jkvshhb1xan",
  "venue": "ChemRxiv",
  "versions": []
}