{
  "abstract": "Senescence is a stress-induced program defined by permanent cell-cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP). Defective clearance of senescent cells promotes inflammation, tissue dysfunction, and ageing, yet determinants of their elimination remain poorly understood. Here, we model oncogene-induced senescence in the hematopoietic system by transplanting Braf V600E - or Braf ΔN -expressing hematopoietic stem and progenitor cells into recipients with distinct immune backgrounds. Braf V600E induces a stronger senescence program and more aggressive disease than Braf ΔN . Survival depends on oncogene-expressing cell burden and host immunity: immunocompetent, lower-burden mice clear oncogene-expressing cells and survive long-term, whereas higher-burden mice show checkpoint upregulation, T-cell exhaustion, and early death. NSG, Rag1KO, and lymphocyte-depleted hosts fail to clear these cells, developing sustained inflammation and bone marrow failure. Rapamycin administration attenuates senescence-associated features and improves survival. These findings identify oncogenic intensity and adaptive immune competence as coupled determinants of senescent-cell fate, with implications for chronic inflammation and senescence-targeted therapies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "Cristina Colleoni",
      "orcid": "0000-0003-4584-9756"
    },
    {
      "name": "Leonardo Ormoli"
    },
    {
      "name": "Pierangela Gallina"
    },
    {
      "name": "Laura Rudilosso"
    },
    {
      "name": "Fabrizio Benedicenti"
    },
    {
      "name": "Martina Rocchi"
    },
    {
      "name": "Rossana Norata"
    },
    {
      "name": "Sara Degl’Innocenti",
      "orcid": "0000-0002-0926-2088"
    },
    {
      "name": "Tommaso Sconocchia",
      "orcid": "0000-0001-8735-7958"
    },
    {
      "name": "Kety Giannetti"
    },
    {
      "name": "Dimitri Bulté"
    },
    {
      "name": "Anna Villa",
      "orcid": "0000-0003-4428-9013"
    },
    {
      "name": "Alessandra Mortellaro",
      "orcid": "0000-0003-1744-2430"
    },
    {
      "name": "Raffaella Di Micco",
      "orcid": "0000-0002-0639-8238"
    },
    {
      "name": "Ivan Merelli",
      "orcid": "0000-0003-3587-3680"
    },
    {
      "name": "Francesca Sanvito",
      "orcid": "0000-0002-4046-8420"
    },
    {
      "name": "Daniela Cesana",
      "orcid": "0000-0001-6366-4224"
    },
    {
      "name": "Eugenio Montini",
      "orcid": "0000-0003-1771-6067"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/26meexxrhg7hr.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-79038-y",
  "fulltext_url": null,
  "id": "26meexxrhg7hr",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-79038-y",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Telomeres, Telomerase, and Senescence"
    ]
  ],
  "openalex": "W7223027545",
  "pdf_url": "https://www.nature.com/articles/s41467-026-79038-y_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-20",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/26meexxrhg7hr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-79038-y",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-79038-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Telomeres, Telomerase, and Senescence",
      "subfield": "physiology"
    }
  ],
  "title": "Oncogenic signalling and host immunocompetency govern senescent cell clearance and systemic inflammation in a mouse model of oncogene-induced senescence",
  "title_text": "Oncogenic signalling and host immunocompetency govern senescent cell clearance and systemic inflammation in a mouse model of oncogene-induced senescence",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/26meexxrhg7hr",
  "venue": "Nature Communications",
  "versions": []
}