{
  "abstract": "Methylthioadenosine phosphorylase (MTAP) loss is an emerging biomarker in several human malignancies, mainly due to its frequent co-deletion with CDKN2A on chromosome 9p21. Beyond its diagnostic value, MTAP deficiency has important biological consequences, including metabolic reprogramming, immune microenvironment modulation, and increased dependency on PRMT5-related pathways. This review summarizes the current evidence on MTAP alterations across different tumor types. The role of MTAP immunohistochemistry as a practical surrogate for CDKN2A homozygous deletion is discussed, together with its advantages and interpretative limitations. In addition, the potential predictive relevance of MTAP loss for immunotherapy, antifolate-based treatments, and novel PRMT5-targeted strategies is explored. Overall, MTAP assessment represents a promising tool in modern diagnostic pathology and precision oncology, bridging morphology, molecular alterations, and therapeutic decision-making.",
  "abstract_shown": true,
  "affiliations": [
    "Pathology Unit, Department of Mental Health and Physic and Preventive Medicine University of Campania “L. Vanvitelli”, 80138 Naples, Italy",
    "Thoracic Surgery Unit, Department of Cardio-Thoracic and Respiratory Sciences, Università degli Studi Della Campania “Luigi Vanvitelli”, 80138 Naples, Italy",
    "Medical Oncology, Department of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anna Diluvio"
    },
    {
      "affs": [
        0
      ],
      "name": "Stefano Lucà"
    },
    {
      "affs": [
        0
      ],
      "name": "Lucia Iavarone"
    },
    {
      "affs": [
        0
      ],
      "name": "Valeria Masola"
    },
    {
      "affs": [
        1
      ],
      "name": "Alfonso Fiorelli",
      "orcid": "0000-0002-0628-613X"
    },
    {
      "affs": [
        2
      ],
      "name": "Floriana Morgillo"
    },
    {
      "affs": [
        0
      ],
      "name": "Giuseppe D’Abbronzo",
      "orcid": "0000-0002-6734-3695"
    },
    {
      "affs": [
        0
      ],
      "name": "Renato Franco"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/270gj92ka12tc.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219653",
  "fulltext_url": null,
  "id": "270gj92ka12tc",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9653",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Cancer-related gene regulation"
    ]
  ],
  "openalex": "W7224079367",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/270gj92ka12tc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:58Z",
      "native_id": "10.3390/ijms27219653",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9653"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Cancer-related gene regulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Beyond Mesothelioma: From Diagnostic Biomarker to Therapeutic Opportunity—The Emerging Role of MTAP in Cancer",
  "title_text": "Beyond Mesothelioma: From Diagnostic Biomarker to Therapeutic Opportunity—The Emerging Role of MTAP in Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:58Z",
  "url": "https://research.draconitic.com/paper/270gj92ka12tc",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}