{
  "abstract": "Minor hallucinations (MHs) affect up to 40% of patients with Parkinson's disease (PD) and are early indicators of cognitive decline. Unlike previous group-level studies, connectome-based brain fingerprinting enables the capture of individualized neural features. Leveraging this framework in a cross-sectional cohort of patients with Parkinson's disease with and without MHs using resting-state functional magnetic resonance imaging, here we show that each patient exhibits a unique brain fingerprint, irrespective of MH status. The most individualized features were associated with clinically relevant measures such as motor-symptom severity and cognitive performance. Patients with MHs showed a loss of individual-specific features in brain networks linked to cognitive health, whereas the cerebellar-to-cortex connectivity-typically less distinctive-became more prominent, emphasizing the role of somatosensory and motor integration in MH pathogenesis. Moreover, MH-related fingerprint regions mapped onto cortical territories with lower densities of neurotransmitter systems implicated in hallucinations. Overall, our fully data-driven findings reveal a distinct, patient-specific signature that differentiates patients with Parkinson's disease and MHs.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Cognitive Neuroscience (LNCO), Neuro-X Institute and Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland",
    "Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland",
    "Neuro X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland",
    "Centre for Human Brain Health, University of Birmingham, Birmingham, UK",
    "School of Mathematics, University of Birmingham, Birmingham, UK",
    "Translational and Clinical Research Institute, Newcastle University, Newcastle, UK",
    "Biomedical Research Institute (IIB-Sant Pau), Barcelona, Spain",
    "Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain",
    "Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain",
    "Universitat Autònoma de Barcelona (UAB), Barcelona, Spain",
    "Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sara Stampacchia",
      "orcid": "0000-0001-9545-3376"
    },
    {
      "affs": [
        0
      ],
      "name": "Fosco Bernasconi",
      "orcid": "0000-0002-7835-6598"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Dimitri Van De Ville",
      "orcid": "0000-0002-2879-3861"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Enrico Amico",
      "orcid": "0000-0001-6705-9689"
    },
    {
      "affs": [
        0
      ],
      "name": "Lada Kohoutová",
      "orcid": "0009-0001-9637-6461"
    },
    {
      "affs": [
        5
      ],
      "name": "John‐Paul Taylor",
      "orcid": "0000-0001-7958-6558"
    },
    {
      "affs": [
        5
      ],
      "name": "Alan J. Thomas",
      "orcid": "0000-0002-6667-9533"
    },
    {
      "affs": [
        6,
        7,
        8,
        9
      ],
      "name": "Javier Pagonabarraga",
      "orcid": "0000-0002-3248-704X"
    },
    {
      "affs": [
        6,
        7,
        8,
        9
      ],
      "name": "Jaime Kulisevsky",
      "orcid": "0000-0003-4870-1431"
    },
    {
      "affs": [
        10,
        0
      ],
      "name": "Olaf Blanke",
      "orcid": "0000-0002-9745-3983"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2772y6r9sstwd.bib",
  "cited_by": 7,
  "doi": "10.1038/s44220-026-00657-x",
  "fulltext_url": null,
  "id": "2772y6r9sstwd",
  "issns": [
    "2731-6076"
  ],
  "landing_url": "https://doi.org/10.1038/s44220-026-00657-x",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|Functional Brain Connectivity Studies"
    ]
  ],
  "openalex": "W7163877003",
  "pdf_url": null,
  "pmcid": "PMC13652722",
  "pmid": "42859526",
  "published": "2026-06-08",
  "publisher": "Springer Science+Business Media",
  "ris": "https://research.draconitic.com/paper/2772y6r9sstwd.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:11Z",
      "native_id": "W7163877003",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s44220-026-00657-x"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Functional Brain Connectivity Studies",
      "subfield": "neuroscience"
    }
  ],
  "title": "Patient-specific functional networks track early cognitive alterations and minor hallucinations in Parkinson’s disease",
  "title_text": "Patient-specific functional networks track early cognitive alterations and minor hallucinations in Parkinson’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:12Z",
  "url": "https://research.draconitic.com/paper/2772y6r9sstwd",
  "venue": "Nature Mental Health",
  "versions": []
}