{
  "abstract": "Objective: To explore bone-quality characteristics in patients with osteoporotic femoral neck fractures by investigating trabecular-bone microstructural and biomechanical alterations of femoral-head specimens and their correlations.\n\nMethods: Femoral-head specimens from 20 patients with osteoporotic femoral neck fractures (experimental group: 69-90 years, 80.65 ± 8.85 years) and 13 patients with early-stage hip degenerative changes (control group: 49-83 years, 64.08 ± 6.93 years) were included. Noticeable baseline age imbalance existed between groups. All specimens underwent Micro-CT scanning. Cylindrical 8-mm-diameter trabecular-bone samples were harvested along principal compressive trabeculae. Compression, bending and torsion tests were conducted to acquire microstructural and biomechanical parameters.\n\nResults: Compared with controls, the experimental group exhibited significantly lower bone volume fraction (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), alongside higher trabecular separation (Tb.Sp) and structural model index (SMI) (all P< 0.05). Biomechanical indicators including maximum compressive stress (MCL), maximum bending force (Fmax) and maximum torque (RST) were markedly reduced in the experimental group (P < 0.05). Trabecular microstructural indices were significantly correlated with biomechanical performance. Of note, baseline age imbalance and potential confounding from hip degenerative pathology should be considered when interpreting inter-group differences.\n\nConclusion: This ex-vivo specimen-based study demonstrates severe trabecular deterioration and impaired biomechanical properties in osteoporotic-fracture specimens, with significant correlations between microstructural damage and reduced mechanical performance. These observations only reflect bone-quality features of isolated specimens; direct extrapolation to predict individual in-vivo fracture risk should be avoided.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedic, Yueyang Hospital Affiliated to Hunan Normal University , , ,",
    "Department of Orthopedic, Second Affiliated Hospital of Xi'an Jiaotong University , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hao Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xu Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenjie Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Pei Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhizheng Xiong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/27gmhx7tqgebw.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1932467",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719394/?tool=EBI",
  "id": "27gmhx7tqgebw",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13719394",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2732|Bone health and osteoporosis research"
    ]
  ],
  "openalex": "W7222529834",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719394/pdf/?tool=EBI",
  "pmcid": "PMC13719394",
  "pmid": "42964204",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/27gmhx7tqgebw.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13719394",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13719394"
    },
    {
      "first_seen": "2026-11-02T12:23:22Z",
      "native_id": "PMC13719394",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1932467"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2732|Bone health and osteoporosis research",
      "subfield": "surgery"
    }
  ],
  "title": "A study on the changes in the microstructure of trabecular bone and the biomechanical properties in patients with osteoporotic fractures and the correlation between them",
  "title_text": "A study on the changes in the microstructure of trabecular bone and the biomechanical properties in patients with osteoporotic fractures and the correlation between them",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:28Z",
  "url": "https://research.draconitic.com/paper/27gmhx7tqgebw",
  "venue": "Frontiers in medicine",
  "versions": []
}