{
  "abstract": "Background: Spontaneous coronary artery dissection is an uncommon cause of acute coronary syndromes, with rare reports in fragile X syndrome.\n\nCase Summary: A 44-year-old man with fragile X syndrome presented with ventricular fibrillation arrest and anterior ST-segment elevation. Angiography and intravascular ultrasound (IVUS) revealed extensive left anterior descending artery spontaneous coronary artery dissection with inadvertent false-lumen wiring. A dual-catheter technique was used, with live false-lumen IVUS-guided true-lumen wiring, hematoma fenestration, and ostial stenting, with postprocedural imaging confirming dissection sealing. Computed tomography angiography identified additional silent dissections of the celiac, superior mesenteric, and right femoral arteries.\n\nDiscussion: This case suggests systemic vascular fragility in fragile X syndrome and describes a novel IVUS-guided bailout strategy using live false-lumen imaging to facilitate true-lumen wiring and ostial stent positioning.\n\nTake-Home Messages: Acute coronary syndrome in fragile X syndrome should prompt consideration of systemic arteriopathy and multivessel dissection. Live false-lumen IVUS may facilitate true-lumen wiring when conventional techniques fail.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Royal Papworth Hospital, Cambridge, United Kingdom"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Majid Anwar"
    },
    {
      "affs": [
        0
      ],
      "name": "Harsh Chawla"
    },
    {
      "affs": [
        0
      ],
      "name": "Thomas Kaier"
    },
    {
      "affs": [
        0
      ],
      "name": "Paul Bambrough"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/27kcxjh19c42r.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jaccas.2026.110387",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13751102/",
  "id": "27kcxjh19c42r",
  "issns": [
    "2666-0849"
  ],
  "landing_url": "https://doi.org/10.1016/j.jaccas.2026.110387",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Case"
    ],
    [
      "heading",
      "Coronary, Peripheral, and Structural Interventions"
    ],
    [
      "openalex",
      "2705|Cardiovascular Issues in Pregnancy"
    ]
  ],
  "openalex": "W7214128833",
  "pdf_url": null,
  "pmcid": "PMC13751102",
  "pmid": "42776114",
  "published": "2026-09-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/27kcxjh19c42r.ris",
  "sources": [
    {
      "first_seen": "2026-11-14T12:23:33Z",
      "native_id": "PMC13751102",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jaccas.2026.110387"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiovascular Issues in Pregnancy",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Spontaneous Coronary Artery Dissection in Fragile X Syndrome",
  "title_text": "Spontaneous Coronary Artery Dissection in Fragile X Syndrome",
  "type": "peer-reviewed",
  "updated_at": "2026-11-14T12:23:33Z",
  "url": "https://research.draconitic.com/paper/27kcxjh19c42r",
  "venue": "JACC Case Reports",
  "versions": []
}