{
  "abstract": "This study explores the role of Sulfatase 1 (SULF1) in the progression of Chronic Obstructive Pulmonary Disease (COPD). SULF1, a modifying enzyme involved in various biological processes, was quantified in human serum using ELISA, and its correlation with lung function was analyzed. The in vivo function of SULF1 was investigated through CRISPR-mediated gene knockout (KO) in mice, and SULF1 overexpression was induced via adeno-associated virus (AAV). A COPD model was established by exposing mice to cigarette smoke (CS). Our findings revealed that SULF1 levels were elevated in the serum of COPD patients, where they negatively correlated with the FEV₁/FVC ratio and the FEV₁/FVC ratio annual decline. In CS-exposed mice, SULF1 expression was downregulated in lung tissues but increased in serum and bronchoalveolar lavage fluid (BALF). SULF1 KO mice exhibited more pronounced emphysematous changes following CS exposure, whereas SULF1 overexpression partially mitigated these lung alterations. Additionally, SULF1 was found to play a protective role in COPD progression through stable binding with Keratin 15 (KRT15). In conclusion, this study elucidates the role of SULF1 in COPD progression, providing novel insights into its pathogenesis and identifying potential therapeutic targets.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China.",
    "Guangzhou National Laboratory, Guangzhou International BioIsland, No.9 Xing Dao Huan Bei Road, Guangzhou, Guangdong, 510005, China.",
    "State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China. pxran@gzhmu.edu.cn.",
    "Guangzhou National Laboratory, Guangzhou International BioIsland, No.9 Xing Dao Huan Bei Road, Guangzhou, Guangdong, 510005, China. pxran@gzhmu.edu.cn.",
    "State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 195 Dongfeng Xi Road, Guangzhou, Guangdong, 510182, China. zhouyumin410@126.com.",
    "Guangzhou National Laboratory, Guangzhou International BioIsland, No.9 Xing Dao Huan Bei Road, Guangzhou, Guangdong, 510005, China. zhouyumin410@126.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Erkang Yi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yue Xi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yujie Zuo"
    },
    {
      "affs": [
        1
      ],
      "name": "Hairong Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaoyu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qianmei Wen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingwei Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyue Mei"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiqing Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Fan Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zihui Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Qi Wan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gaoying Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoyang Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Ruiting Sun"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Pixin Ran"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Yumin Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/27kz14gnxbenm.bib",
  "cited_by": 0,
  "doi": "10.1186/s12931-026-03818-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13679013",
  "id": "27kz14gnxbenm",
  "issns": [
    "1465-9921",
    "1465-993X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42894165",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC705-779"
    ],
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      "openalex",
      "2740|Chronic Obstructive Pulmonary Disease (COPD) Research"
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  "pdf_url": "https://europepmc.org/articles/PMC13679013?pdf=render",
  "pmcid": "PMC13679013",
  "pmid": "42894165",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/27kz14gnxbenm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:42Z",
      "native_id": "MED:42894165",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42894165"
    },
    {
      "first_seen": "2026-10-30T13:46:29Z",
      "native_id": "ed3b50c753d544ffac1e3f23d86841de",
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      "url": "https://doi.org/10.1186/s12931-026-03818-9"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Chronic Obstructive Pulmonary Disease (COPD) Research",
      "subfield": "general"
    }
  ],
  "title": "A novel protective role for SULF1 in chronic obstructive pulmonary disease through systemic compensation and binding to KRT15.",
  "title_text": "A novel protective role for SULF1 in chronic obstructive pulmonary disease through systemic compensation and binding to KRT15.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:29Z",
  "url": "https://research.draconitic.com/paper/27kz14gnxbenm",
  "venue": "Respiratory research",
  "versions": []
}