{
  "abstract": "Systemic iron sequestration occurs frequently in cancer due to inflammation-driven expression of the iron-regulatory hormone hepcidin. The impact of systemic iron availability on tumoral immunity is unclear. Here, we show that elevated serum hepcidin is associated with reduced survival and decreased intratumoral CD8+ T cells in patients with pancreas cancer. While hepcidin is not induced in murine tumor models, administration of a hepcidin mimetic phenocopies the T-cell-depleted tumor microenvironment seen in patients. Mechanistically, chronic antigen-driven mitochondrial dysfunction disrupts iron metabolism and selectively depletes high avidity CD8+ T cells during iron restriction. These findings establish a direct link between hepcidin-mediated iron sequestration and tumoral immunity and nominate systemic iron dysregulation as a therapeutic target to enhance anti-tumoral CD8+ T cell responses.",
  "abstract_shown": true,
  "affiliations": [
    "Memorial Sloan Kettering Cancer Center"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "name": "J. Schoenfeld"
    },
    {
      "name": "J. Noel"
    },
    {
      "name": "C. McGinnis"
    },
    {
      "name": "C. Fu"
    },
    {
      "name": "B. Alagesan"
    },
    {
      "name": "E. Hernandez"
    },
    {
      "name": "J. Jee"
    },
    {
      "name": "N. Schultz"
    },
    {
      "name": "Q. Morris"
    },
    {
      "name": "S. Lowe"
    },
    {
      "name": "S. Cloonan"
    },
    {
      "name": "J. Connolly"
    },
    {
      "name": "R. Chaligne"
    },
    {
      "name": "D. Kelsen"
    },
    {
      "name": "K. Yu"
    },
    {
      "name": "W. Zhang"
    },
    {
      "name": "E. OReilly"
    },
    {
      "name": "A. Satpathy"
    },
    {
      "name": "T. Ganz"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Vardhana"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/27tecd0e5bsn3.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.21.753167",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753167v1.full",
  "id": "27tecd0e5bsn3",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753167v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ],
    [
      "openalex",
      "2720|Iron Metabolism and Disorders"
    ]
  ],
  "openalex": "W7214503420",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753167v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/27tecd0e5bsn3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:37Z",
      "native_id": "10.64898/2026.09.21.753167",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753167v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Systemic iron sequestration restricts the intratumoral CD8+ T cell landscape in pancreas cancer",
  "title_text": "Systemic iron sequestration restricts the intratumoral CD8+ T cell landscape in pancreas cancer",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:37Z",
  "url": "https://research.draconitic.com/paper/27tecd0e5bsn3",
  "venue": "bioRxiv",
  "versions": []
}