{
  "abstract": "Autoimmune cerebellar ataxia (ACA) is an immune-mediated cerebellar syndrome that is often associated with specific autoantibodies. We report a case of a 61-year-old man with small cell lung cancer who developed subacute progressive cerebellar ataxia after durvalumab therapy. Anti-P/Q-type voltage-gated calcium channel (VGCC) and anti-metabotropic glutamate receptor 5 (mGluR5) antibodies were detected. The patient improved substantially with early immunotherapy and the discontinuation of immune checkpoint inhibitor (ICIs) therapy. In this case, anti-VGCC antibodies may have contributed to the pathophysiology. However, anti-mGluR5 antibodies were also detected. The relationship between ACA and ICIs therapy remains unclear, and additional cases are needed.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 25,
  "authors": [
    {
      "name": "Shuntaro Nakamura"
    },
    {
      "name": "Kazuki Yamada"
    },
    {
      "name": "Hiroaki Yaguchi"
    },
    {
      "name": "Akihiko Kudo"
    },
    {
      "name": "Shintaro Fujii"
    },
    {
      "name": "Taichi Nomura"
    },
    {
      "name": "Shoki Sato"
    },
    {
      "name": "Taishi Iwanami"
    },
    {
      "name": "Kaiki Kawakita"
    },
    {
      "name": "Hanko Sato"
    },
    {
      "name": "Keita Majima"
    },
    {
      "name": "Kei Oiwa"
    },
    {
      "name": "Kosuke Iwami"
    },
    {
      "name": "Daiki Tanaka"
    },
    {
      "name": "Katsuki Eguchi"
    },
    {
      "name": "Hisashi Uwatoko"
    },
    {
      "name": "Shinichi Shirai"
    },
    {
      "name": "Ikuko Takahashi-Iwata"
    },
    {
      "name": "Masaaki Matsushima"
    },
    {
      "name": "Doppo Fukui"
    },
    {
      "name": "Megumi Furuta"
    },
    {
      "name": "Fumitaka Shimizu"
    },
    {
      "name": "Keiko Tanaka"
    },
    {
      "name": "Satoshi Konno"
    },
    {
      "name": "Ichiro Yabe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/284jcch3bq3be.bib",
  "cited_by": 1,
  "doi": "10.2169/internalmedicine.7680-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7680-26/_article",
  "id": "284jcch3bq3be",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7680-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2728|Autoimmune Neurological Disorders and Treatments"
    ]
  ],
  "openalex": "W7214576246",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7680-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/284jcch3bq3be.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7680-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7680-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Autoimmune Neurological Disorders and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Immune Checkpoint Inhibitor Therapy Triggers Autoimmune Cerebellar Ataxia with Anti-P/Q-type VGCC Antibody and Anti-mGluR5 Antibodies: A Case Report",
  "title_text": "Immune Checkpoint Inhibitor Therapy Triggers Autoimmune Cerebellar Ataxia with Anti-P/Q-type VGCC Antibody and Anti-mGluR5 Antibodies: A Case Report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/284jcch3bq3be",
  "venue": "Internal Medicine",
  "versions": []
}