{
  "abstract": "Background and Aims. Systemic hypercoagulability is a recognized hallmark of malignancy. Growing evidence suggests that markers of hemostatic activation may serve as surrogates for tumor aggressiveness and prognosis, other than thrombosis; however, a comprehensive characterization of this \"hemostatic signature\" within an inflammatory milieu across large prospective cohorts remains limited. This study aims to evaluate tumor-specific procoagulant profiles within a large, prospective, multicenter cohort of patients diagnosed with common solid malignancies. Methods. We analyzed 4,292 patients from the HYPERCAN study (NCT02622815) with newly diagnosed non-small cell lung (NSCLC), gastric (GC), colorectal (CRC), and breast cancer (BC). Plasma samples were collected at diagnosis to assess thrombin generation (TG_CAT), D-dimer, fibrinogen, and prothrombin fragment 1+2 (F1+2). All participants provided informed consent, and data were analyzed using SPSS 21.0. Results. Metastatic disease was predominant in the NSCLC (67%), GC (53%), and CRC (47%) cohorts, whereas 75% of the BC cohort consisted of high-risk surgically resected patients. Fibrinogen levels were significantly elevated in metastatic cases compared with resected cases across all tumor types (p < 0.001), with the highest concentrations observed in metastatic NSCLC. Notably, CRC exhibited a stage-dependent, stepwise increase in fibrinogen (348 to 444 mg/dL; p < 0.05). While FVIII was consistently higher in metastatic groups (except GC), D-dimer peaks were most pronounced in metastatic GC and NSCLC (p < 0.002). Although F1+2 effectively differentiated metastatic from localized disease in NSCLC, GC, and BC (p < 0.05), it showed no discriminatory power in CRC. Finally, the highest TG-Peak and ETP values were found in BC and NSCLC; in the latter, TG values positively correlated with disease burden, significantly distinguishing metastatic from resected patients (p < 0.003). Conclusions. These data demonstrate that cancer-associated hypercoagulability is a heterogeneous, tumor-specific hallmark rather than a uniform systemic event. While fibrinogen and D-dimer remain robust indicators of metastatic progression—particularly in NSCLC and GC—the sensitivity of markers like F1+2 and TG varies by histotype. These findings underscore the necessity of tailored hemostatic profiling to better understand biological heterogeneity and improve risk stratification across diverse malignancies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Marina Marchetti"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2861ttp07h38a.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "https://www.btvb.org/btvb/article/view/712",
  "id": "2861ttp07h38a",
  "issns": [
    "2785-5309"
  ],
  "landing_url": "https://www.btvb.org/btvb/article/view/712",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC666-701"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "PAGEPress Publications",
  "ris": "https://research.draconitic.com/paper/2861ttp07h38a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:29Z",
      "native_id": "481ad9e2d6d84c44b59aaddda7152d39",
      "source": "doaj",
      "url": "https://www.btvb.org/btvb/article/view/712"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC666-701",
      "subfield": "cardiovascular"
    }
  ],
  "title": "CO010 | MAPPING HEMOSTATIC BIOMARKER EXPRESSION ACROSS CANCER TYPES AND STAGES WITHIN THE HYPERCAN COHORT",
  "title_text": "CO010 | MAPPING HEMOSTATIC BIOMARKER EXPRESSION ACROSS CANCER TYPES AND STAGES WITHIN THE HYPERCAN COHORT",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:29Z",
  "url": "https://research.draconitic.com/paper/2861ttp07h38a",
  "venue": "Bleeding, Thrombosis and Vascular Biology",
  "versions": []
}