{
  "abstract": "Purpose\n\nWe aimed to optimize antiemetic strategies by evaluating the association of co-administration of neurokinin-1 receptor antagonist (NK1-RA) administration and dexamethasone on new-onset diabetes in patients receiving chemotherapy.Methods\n\nThis retrospective cross-sectional study was conducted using the DeSC database and included patients aged ≥ 18 years with solid tumors who initiated parenteral anticancer agents and dexamethasone between April 2014 and March 2023. Patients with a history of diabetes or hematologic malignancies were excluded. The primary outcome was new-onset diabetes during the 2 months following the index month, defined by International Classification of Diseases, Tenth Revision codes or prescription data. Multivariable logistic regression assessed the association between co-administration of NK1-RA and dexamethasone and new-onset diabetes.Results\n\nAmong 71,539 eligible patients, 51.1% received NK1-RAs. Co-administration of NK1-RA and dexamethasone was significantly associated with an increased risk of new-onset diabetes (adjusted odds ratio: 1.43; 95% confidence interval: 1.31-1.55; p < 0.001). Sensitivity analyses demonstrated consistent results across different evaluation periods and outcome definitions.Conclusion\n\nCo-administration of NK1-RA and dexamethasone was associated with an increased risk of new-onset diabetes. These findings highlight a previously unrecognized safety signal and support the careful management of dexamethasone, as recommended by many clinical guidelines.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.",
    "Department of Pharmacy, Kanagawa Prefectural Keiyukai, Keiyu Hospital, Kanagawa, Japan.",
    "Drug Informatics Group, Laboratory of Clinical Pharmacy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji-City, Tokyo, 192-0392, Japan. ssuzuki@toyaku.ac.jp.",
    "Drug Informatics Group, Laboratory of Clinical Pharmacy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji-City, Tokyo, 192-0392, Japan.",
    "Division of Pharmacoepidemiology, Showa Medical University Graduate School of Pharmacy, Tokyo, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yuki Ozawa",
      "orcid": "0000-0002-5804-9128"
    },
    {
      "affs": [
        2
      ],
      "name": "Shinya Suzuki",
      "orcid": "0009-0006-5032-171X"
    },
    {
      "affs": [
        3
      ],
      "name": "Takuma Koinuma",
      "orcid": "0009-0003-6338-7396"
    },
    {
      "affs": [
        0
      ],
      "name": "Takashi Yokokawa",
      "orcid": "0000-0001-9988-128X"
    },
    {
      "affs": [
        3
      ],
      "name": "Takenori Ichimura",
      "orcid": "0000-0002-4731-6032"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenichi Suzuki",
      "orcid": "0000-0002-4682-4369"
    },
    {
      "affs": [
        3
      ],
      "name": "Yusuke Hori"
    },
    {
      "affs": [
        4
      ],
      "name": "Shinobu Imai",
      "orcid": "0000-0003-1784-5133"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/28esk8n6v7j1p.bib",
  "cited_by": 0,
  "doi": "10.1007/s00520-026-11414-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13719788",
  "id": "28esk8n6v7j1p",
  "issns": [
    "0941-4355",
    "1433-7339"
  ],
  "landing_url": "https://europepmc.org/article/MED/42955428",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2746|Nausea and vomiting management"
    ]
  ],
  "openalex": "W7224228011",
  "pdf_url": "https://europepmc.org/articles/PMC13719788?pdf=render",
  "pmcid": "PMC13719788",
  "pmid": "42955428",
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/28esk8n6v7j1p.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:36Z",
      "native_id": "MED:42955428",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42955428"
    },
    {
      "first_seen": "2026-11-02T12:23:41Z",
      "native_id": "PMC13719788",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00520-026-11414-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Nausea and vomiting management",
      "subfield": "surgery"
    }
  ],
  "title": "Association of co-administration of neurokinin-1 receptor antagonists and dexamethasone with new-onset diabetes in patients receiving chemotherapy: a retrospective cross-sectional study using health claims database in Japan.",
  "title_text": "Association of co-administration of neurokinin-1 receptor antagonists and dexamethasone with new-onset diabetes in patients receiving chemotherapy: a retrospective cross-sectional study using health claims database in Japan.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:47Z",
  "url": "https://research.draconitic.com/paper/28esk8n6v7j1p",
  "venue": "Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer",
  "versions": []
}