{
  "abstract": "We developed a new hybrid bilayer membrane (HBM) platform, Fe(TPY)(CN)3 HBM, incorporating mononuclear Fe complexes chelated by tridentate 2,2':6',2''-terpyridine-4'-oxy-hexane-1-thiol (TPY) ligands and cyanide (CN–) ligands on an Au electrode, forming a stable and robust octahedral complex, covered by a monolayer of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipids, to study the transmembrane diffusion behaviours of monovalent cations, Li+, Na+, K+ and NH4+. The most positive shift in the half-wave potential (E1/2) of Fe3+/2+ redox occurred in presence of Li+, following the descending trend of Li+ > NH4+ > Na+ > K+. On the other hand, the Fe3+/2+ redox exhibited the largest peak separation (ΔE) in presence of Li+, which follows the same descending order. These trends highlight that the transmembrane diffusion mechanism for the monovalent cations studied is governed by interplay of charge density, intermolecular interactions, dehydration energy, and interfacial steric hindrance.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry",
    "University of Hong Kong",
    "Centre for Condensed Matter Sciences and Centre of Atomic Initiative for New Materials",
    "National Taiwan University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Hei Tung Yau"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zuo Hang Yu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaoyong Mo"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Sheng-Yu Yu"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Heng-Liang Wu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Edmund C. M. Tse",
      "orcid": "0000-0002-9313-1290"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/28meh0mmcvxe9.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008176/v1",
  "fulltext_url": null,
  "id": "28meh0mmcvxe9",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008176/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Lipid Membrane Structure and Behavior"
    ]
  ],
  "openalex": "W7204999927",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008176/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/28meh0mmcvxe9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:17Z",
      "native_id": "10.26434/chemrxiv.15008176",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008176/v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Lipid Membrane Structure and Behavior",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Studying Biologically Important Monovalent Cation Diffusion across Lipids Using Molecular Fe Redox Reporters in Hybrid Bilayer Membranes",
  "title_text": "Studying Biologically Important Monovalent Cation Diffusion across Lipids Using Molecular Fe Redox Reporters in Hybrid Bilayer Membranes",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:17Z",
  "url": "https://research.draconitic.com/paper/28meh0mmcvxe9",
  "venue": "ChemRxiv",
  "versions": []
}