{
  "abstract": "Objective: To characterize serum metabolic alterations across healthy controls, stable chronic obstructive pulmonary disease (SCOPD), and acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to explore candidate discriminatory metabolites for COPD-related comparisons.\n\nResults: Serum samples from 19 patients with SCOPD, 20 patients with AECOPD, and 20 non-smoking healthy controls were analyzed by LC-MS/MS-based untargeted metabolomics. COPD groups showed reduced glycerophospholipid and alpha-linolenic acid metabolism compared with controls, whereas AECOPD showed enrichment of unsaturated fatty acid biosynthesis compared with SCOPD. PE(16:1(5Z)/16:1(5Z)) and 14,15-leukotriene C4 showed exploratory discriminatory potential in COPD-versus-control and AECOPD-versus-SCOPD comparisons, respectively. Because the study was small and lacked external validation, these metabolites should be interpreted as hypothesis-generating candidates requiring targeted validation.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13104-026-07969-2.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pulmonary and Critical Care Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092 China",
    "Institute of Translational Medicine, Shanghai University, Shanghai, 200444 China",
    "Department of Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yue Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinru Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Pengyuan Zhuang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuejun Guo"
    },
    {
      "affs": [
        2
      ],
      "name": "Jun Shen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/28tq6495jzff2.bib",
  "cited_by": 0,
  "doi": "10.1186/s13104-026-07969-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737701/",
  "id": "28tq6495jzff2",
  "issns": [
    "1756-0500"
  ],
  "landing_url": "https://doi.org/10.1186/s13104-026-07969-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Note"
    ],
    [
      "openalex",
      "2740|Chronic Obstructive Pulmonary Disease (COPD) Research"
    ]
  ],
  "openalex": "W7201964624",
  "pdf_url": null,
  "pmcid": "PMC13737701",
  "pmid": "42983589",
  "published": "2026-08-08",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/28tq6495jzff2.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:49Z",
      "native_id": "PMC13737701",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13104-026-07969-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Chronic Obstructive Pulmonary Disease (COPD) Research",
      "subfield": "general"
    }
  ],
  "title": "Metabolomic profiling reveals candidate discriminatory metabolites in stable chronic obstructive pulmonary disease and acute exacerbation",
  "title_text": "Metabolomic profiling reveals candidate discriminatory metabolites in stable chronic obstructive pulmonary disease and acute exacerbation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:49Z",
  "url": "https://research.draconitic.com/paper/28tq6495jzff2",
  "venue": "BMC Research Notes",
  "versions": []
}