{
  "abstract": "Introduction: Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord (SC) dysfunction. Conventional MRI, particularly T2-weighted imaging, depicts SC changes well but often fails to provide satisfactory clinico-radiological correlation. We assessed the value of quantitative perfusion MRI-specifically Golden-angle RAdial Sparse Parallel (GRASP) Dynamic Contrast-Enhanced (DCE) MRI. Materials and methods: Thirteen patients with chronic-onset DCM were enrolled. Clinical status was assessed using the modified Japanese Orthopaedic Association (mJOA) scale. Sagittal cervical SC T2-w 3D SPACE imaging and GRASP-DCE mapping were performed at baseline (M0) and 3 months postoperatively (M3). Semiquantitative parameters-area under the curve (AUC60), wash-in (WI), and wash-out (WO)-were derived from time-signal intensity curves to compare regional perfusion pre-and postoperatively. Patients were divided into good (>30%) and poor (<30%) recovery groups based on postoperative mean mJOA Recovery Rate (RR). Results: mJOA grade was mild in 4 patients, moderate in 7, and severe in 2. SC compression was multi-level in 4. Mean postoperative RRmJOA was 31.6% ± 58%. Mean M0 and M3 AUC60, WI, and WO values in the whole cord and compressed zone showed no significant difference across the whole population. However, in the 8 patients with RRmJOA >30%, mean whole-cord AUC60 was significantly higher at M0 than M3 (48.0 ± 7.8 vs. 39.7 ± 6.7; p = 0.024). Conversely, AUC60 and WI increased in the poor-recovery group. Conclusion: GRASP-DCE MRI offers valuable insight into SC perfusion. Divergent AUC60/WI patterns by recovery status suggest two distinct compensatory pathophysiological mechanisms, highlighting the complexity of disease and recovery.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Kaissar Farah"
    },
    {
      "name": "Guillaume Frébourg"
    },
    {
      "name": "Lauriane Pini"
    },
    {
      "name": "Thomas Troalen"
    },
    {
      "name": "Maxime Guye"
    },
    {
      "name": "Stéphane Fuentes"
    },
    {
      "name": "Pierre-Hugues Roche"
    },
    {
      "name": "Virginie Callot"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/28vs2rmjxjt1f.bib",
  "cited_by": 0,
  "doi": "10.1016/j.neuchi.2026.101862",
  "fulltext_url": null,
  "id": "28vs2rmjxjt1f",
  "issns": [
    "0028-3770",
    "1773-0619"
  ],
  "landing_url": "https://amu.hal.science/hal-05854820v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.ib"
    ],
    [
      "hal",
      "2.sdv.ib.ima"
    ],
    [
      "openalex",
      "2746|Cervical and Thoracic Myelopathy"
    ]
  ],
  "openalex": "W7170199330",
  "pdf_url": "https://amu.hal.science/hal-05854820/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/28vs2rmjxjt1f.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:25Z",
      "native_id": "hal-05854820",
      "source": "hal",
      "url": "https://amu.hal.science/hal-05854820v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ib",
      "subfield": "systems-synthetic"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.ib.ima",
      "subfield": "imaging"
    }
  ],
  "title": "Pre and postoperative perfusion MRI in degenerative cervical myelopathy suggest different patterns of pathophysiological compensatory mechanisms",
  "title_text": "Pre and postoperative perfusion MRI in degenerative cervical myelopathy suggest different patterns of pathophysiological compensatory mechanisms",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:25Z",
  "url": "https://research.draconitic.com/paper/28vs2rmjxjt1f",
  "venue": "Neurochirurgie",
  "versions": []
}