{
  "abstract": "Sanguinarine (SAN), a natural alkaloid derived from Papaveraceae plants, is an active component in traditional Chinese medicines. SAN exerts inhibitory effects on tumor cells, but research on its effects on lung adenocarcinoma (LUAD) and the underlying mechanisms remains limited. The Hippo signaling pathway is commonly downregulated in LUAD, making it a key target for therapeutic intervention. Our study reveals that SAN significantly inhibits LUAD. Mechanistically, SAN bound to Large Tumor Suppressor 1 (LATS1) and promoted its phosphorylation, thereby activating the Hippo pathway and pyroptosis in LUAD. Notably, YAP overexpression inhibited pyroptosis and weakened the antitumor effect of SAN, further confirming that SAN exerts its antitumor effects by regulating the Hippo-YAP axis. Findings from both in vivo experiments and single-cell RNA sequencing consistently show that SAN remodels the tumor immune microenvironment and inhibits tumor growth. Specifically, we observed significant changes in the tumor microenvironment, including increased CD8⁺ T cell infiltration and a notably reduced number of myofibroblastic cancer-associated fibroblasts. Collectively, our findings establish SAN as a candidate therapeutic agent that exerts antitumor effects through dual modulation of the Hippo-mediated pyroptosis pathway and tumor immunity, providing a mechanistic basis for its potential clinical application in LUAD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oncology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.",
    "Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shanghai Pudong Hospital, Fudan University, Shanghai 200032, China.",
    "Fudan University Shanghai Cancer Center, Shanghai 200032, China.",
    "Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.",
    "Bayinguoleng Mongolian Autonomous Prefecture Hygiene School, Xinjiang Province 841000, China.",
    "Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.",
    "Institute of Respiratory Diseases, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jia Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Lanfang Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Yunjian Pan"
    },
    {
      "affs": [
        1
      ],
      "name": "Wulei Hou"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiaoyan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhengda Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Wenjie Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yihua Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Ping Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Lifang Wang"
    },
    {
      "affs": [
        5
      ],
      "name": "Ying Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhongqi Wang"
    },
    {
      "affs": [
        6
      ],
      "name": "Zhenhui Lu"
    },
    {
      "affs": [
        1
      ],
      "name": "Zuoyun Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/291d8x0bnxegh.bib",
  "cited_by": 0,
  "doi": "10.7150/ijbs.139061",
  "fulltext_url": "https://europepmc.org/articles/PMC13686061",
  "id": "291d8x0bnxegh",
  "issns": [
    "1449-2288"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910301",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7221470026",
  "pdf_url": "https://europepmc.org/articles/PMC13686061?pdf=render",
  "pmcid": "PMC13686061",
  "pmid": "42910301",
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/291d8x0bnxegh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910301",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910301"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Sanguinarine Induces Pyroptosis via the Hippo Signaling Pathway and Remodels the Tumor Immune Microenvironment in Lung Adenocarcinoma.",
  "title_text": "Sanguinarine Induces Pyroptosis via the Hippo Signaling Pathway and Remodels the Tumor Immune Microenvironment in Lung Adenocarcinoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/291d8x0bnxegh",
  "venue": "International journal of biological sciences",
  "versions": []
}