{
  "abstract": "Objectives: To characterise the sociodemographic patterning of neuroticism and evaluate its associations with major mental and physical diseases in Chinese adults.\n\nStudy design: Prospective cohort study of 25,041 adults from 5 urban and 5 rural areas in China, participating in the second resurvey of the China Kadoorie Biobank in 2013–2014.\n\nMethods: Neuroticism was assessed using the 23-item Eysenck Personality Questionnaire and expressed as a neuroticism score (N-score). Logistic regression examined cross-sectional associations of N-score with socioeconomic characteristics and prevalence of mental and general health conditions, while Cox regression assessed prospective associations of N-score with incidence of major diseases identified through linkage to electronic health registries.\n\nResults: Mean N-score was 2.52 and was higher in women and urban residents, with a clear downward trend with age. A higher N-score was strongly associated with socioeconomic disadvantage, including not being in marriage and having a lower level of household income. Compared with participants with an N-score of 0, those with an N-score ≥ 4 had a higher prevalence of mental health problems and poor general health, with adjusted risk ratios ranging from 1.52 to 41.01. Prospectively, a higher N-score was significantly associated with higher risks of ischaemic heart disease, stroke, mental and behavioural disorders, and nervous and digestive system diseases (hazard ratios 1.17–1.81 for the highest versus lowest N-score group).\n\nConclusions: Neuroticism showed substantial sociodemographic patterning and was associated with a broad range of mental and physical health outcomes. These findings highlight its potential relevance to population health and risk stratification.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 159,
  "authors": [
    {
      "name": "Ruixin He"
    },
    {
      "name": "Huaidong Du"
    },
    {
      "name": "Jonathan Clarke"
    },
    {
      "name": "Baihan Wang"
    },
    {
      "name": "Ling Yang"
    },
    {
      "name": "Pei Pei"
    },
    {
      "name": "Dianjianyi Sun"
    },
    {
      "name": "Jun Lv"
    },
    {
      "name": "Canqing Yu"
    },
    {
      "name": "Xiaoming Yang"
    },
    {
      "name": "Xiaohui Sun"
    },
    {
      "name": "Junshi Chen"
    },
    {
      "name": "Liming Li"
    },
    {
      "name": "Zhengming Chen"
    },
    {
      "name": "Yiping Chen"
    },
    {
      "name": "for the China Kadoorie Biobank Collaborative Group"
    },
    {
      "name": "Robert Clarke"
    },
    {
      "name": "Rory Collins"
    },
    {
      "name": "Richard Peto"
    },
    {
      "name": "Robin Walters"
    },
    {
      "name": "Daniel Avery"
    },
    {
      "name": "Maxim Barnard"
    },
    {
      "name": "Derrick Bennett"
    },
    {
      "name": "Ruth Boxall"
    },
    {
      "name": "Ka Hung Chan"
    },
    {
      "name": "Zhengming Chen"
    },
    {
      "name": "Charlotte Clarke"
    },
    {
      "name": "Robert Clarke"
    },
    {
      "name": "Ahmed Edris Mohamed"
    },
    {
      "name": "Hannah Fry"
    },
    {
      "name": "Simon Gilbert"
    },
    {
      "name": "Pek Kei Im"
    },
    {
      "name": "Andri Iona"
    },
    {
      "name": "Maria Kakkoura"
    },
    {
      "name": "Christiana Kartsonaki"
    },
    {
      "name": "Kshitij Kolhe"
    },
    {
      "name": "Hubert Lam"
    },
    {
      "name": "Kuang Lin"
    },
    {
      "name": "James Liu"
    },
    {
      "name": "Mohsen Mazidi"
    },
    {
      "name": "Iona Millwood"
    },
    {
      "name": "Sam Morris"
    },
    {
      "name": "Qunhua Nie"
    },
    {
      "name": "Alfred Pozarickij"
    },
    {
      "name": "Maryam Rahmati"
    },
    {
      "name": "Paul Ryder"
    },
    {
      "name": "Dan Schmidt"
    },
    {
      "name": "Becky Stevens"
    },
    {
      "name": "Iain Turnbull"
    },
    {
      "name": "Robin Walters"
    },
    {
      "name": "Lin Wang"
    },
    {
      "name": "Neil Wright"
    },
    {
      "name": "Pang Yao"
    },
    {
      "name": "Xiao Han"
    },
    {
      "name": "Can Hou"
    },
    {
      "name": "Qingmei Xia"
    },
    {
      "name": "Chao Liu"
    },
    {
      "name": "Lang Pan"
    },
    {
      "name": "Zengchang Pang"
    },
    {
      "name": "Ruqin Gao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/292wqvq6grw7b.bib",
  "cited_by": 0,
  "doi": "10.1186/s12889-026-29670-6",
  "fulltext_url": null,
  "id": "292wqvq6grw7b",
  "issns": [
    "1471-2458"
  ],
  "landing_url": "https://link.springer.com/10.1186/s12889-026-29670-6",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3203|Personality Traits and Psychology"
    ]
  ],
  "openalex": "W7216308817",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/292wqvq6grw7b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:54Z",
      "native_id": "10.1186/s12889-026-29670-6",
      "source": "crossref",
      "url": "https://link.springer.com/10.1186/s12889-026-29670-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3203|Personality Traits and Psychology",
      "subfield": "psychiatry"
    }
  ],
  "title": "Patterns and health relevance of neuroticism in Chinese men and women: evidence from the China Kadoorie Biobank",
  "title_text": "Patterns and health relevance of neuroticism in Chinese men and women: evidence from the China Kadoorie Biobank",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:54Z",
  "url": "https://research.draconitic.com/paper/292wqvq6grw7b",
  "venue": "BMC Public Health",
  "versions": []
}