{
  "abstract": "Breast cancer (BC) and type 2 diabetes mellitus (T2DM) often co-occur and can contribute to poorer clinical outcomes after therapy compared to non-diabetic cases. It is assumed that glucose-lowering drugs like DPP4 inhibitors (DPP4-Is), e.g., sitagliptin, can affect the radiation responses of BC cells. In this study, parental and invasive (INV) MDA-MB-231 (triple-negative BC) and T47D (luminal A) cells were used. INV cells revealed a significant upregulation of DPP4/CD26 molecules compared to their parental counterparts. All investigated cells were treated with sitagliptin, ionizing radiation, or both. It was found that the specific inhibition of DPP4/CD26 molecules using sitagliptin can protect triple-negative BC cells from cytotoxic ionizing radiation or improve the radiation response in luminal A BC cells independently of their metastatic abilities. The protective and sensitizing effects of sitagliptin do not depend on the level of senescence and/or autophagy initiation after treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria",
    "Laboratory for Experimental and Translational Research on Radio-Oncology (EXTRO-Lab), Department of Radiation Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria",
    "Tyrolean Cancer Research Institute, 6020 Innsbruck, Austria",
    "Department of Pediatrics II, Medical University of Innsbruck, 6020 Innsbruck, Austria"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Marie Theres Eling"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Anouk Bottema"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Dragana Savic",
      "orcid": "0000-0001-5196-4676"
    },
    {
      "affs": [
        0
      ],
      "name": "Sergej Skvortsov"
    },
    {
      "affs": [
        0
      ],
      "name": "Ute Ganswindt"
    },
    {
      "affs": [
        3
      ],
      "name": "Petra Obexer"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ira Ida Skvortsova",
      "orcid": "0000-0001-8993-611X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/299qgptf9h7eb.bib",
  "cited_by": 0,
  "doi": "10.3390/cells15201879",
  "fulltext_url": "https://europepmc.org/articles/PMC13702927",
  "id": "299qgptf9h7eb",
  "issns": [
    "2073-4409"
  ],
  "landing_url": "https://www.mdpi.com/2073-4409/15/20/1879",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Metabolism, Diabetes, and Cancer"
    ]
  ],
  "openalex": "W7222172636",
  "pdf_url": "https://europepmc.org/articles/PMC13702927?pdf=render",
  "pmcid": "PMC13702927",
  "pmid": "42929851",
  "published": "2026-10-15",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/299qgptf9h7eb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:02Z",
      "native_id": "10.3390/cells15201879",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4409/15/20/1879"
    },
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929851",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929851"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Metabolism, Diabetes, and Cancer",
      "subfield": "molecular-biology"
    }
  ],
  "title": "The Impact of the Antidiabetic Agent Sitagliptin on the Radiation Response of Breast Carcinoma Cells with Different Metastatic Capacities",
  "title_text": "The Impact of the Antidiabetic Agent Sitagliptin on the Radiation Response of Breast Carcinoma Cells with Different Metastatic Capacities",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/299qgptf9h7eb",
  "venue": "Cells",
  "versions": []
}