{
  "abstract": "Sustained contemplative practice confers well-documented psychological and physiological benefits, yet the experiential deepening that motivates practitioners can require many hours of practice, and mastery is not assured. Methods that accelerate training would broaden access to these benefits and could also test mechanism: the posterior cingulate cortex (PCC), caudate, and anterior insula are implicated in meditation, but only correlationally. We used low-intensity transcranial focused ultrasound (FUS) to ask whether reversibly perturbing each region shifts meditative experience in real time. In a single-blind, sham-controlled, counterbalanced crossover design, long-term practitioners of insight meditation in the S.N. Goenka Vipassana tradition (LTMs; n = 36) and meditation-naïve novices (n = 12; an exploratory cohort; meditation experience not randomized) received 12 minutes of inhibition-biased (5% duty cycle) FUS to the PCC, bilateral caudate, or bilateral anterior insula, or sham, in separate sessions during hour-long meditation. Every ~4 minutes, participants rated meditative depth (anchored from “extremely shallow” to “extremely deep”) and intensity (relative to their normal experience, along any dimension), with autonomic, mood, and trait measures as secondary outcomes. Sham-relative changes in rating trajectories were tested with generalized linear mixed models and false discovery rate (FDR)-corrected contrasts. In LTMs, caudate stimulation produced a significantly steeper rise in depth than sham and insula stimulation; in novices, PCC stimulation produced a significantly steeper rise in depth than sham, caudate, and insula stimulation, such that the caudate-versus-PCC difference in depth slopes differed significantly between groups, reversing in sign. No target altered intensity relative to sham, insula stimulation had no sham-relative effect on meditation, and post-session mood and trait measures were unchanged. Autonomic effects were modest and did not account for the meditative effects, and expectation of benefit did not differ across conditions in LTMs. FUS neuromodulation can causally and region-specifically accelerate meditative deepening, with the effective target differing by meditation experience (caudate in LTMs, PCC in novices), a dependence that may reflect practice itself or its correlates. Tempered by the single-blind protocol, the small novice cohort, and effects extending beyond sonication, these findings establish proof-of-principle for neuromodulatory facilitation of meditation and motivate individualized, closed-loop applications.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Joshua Cain"
    },
    {
      "name": "Micah Johnson"
    },
    {
      "name": "Amirvala Tavakoli"
    },
    {
      "name": "Tracy Brandmeyer"
    },
    {
      "name": "Ninette Simonian"
    },
    {
      "name": "Geena Wang"
    },
    {
      "name": "Jezabel May"
    },
    {
      "name": "Alexander Bystritsky"
    },
    {
      "name": "Shinzen Young"
    },
    {
      "name": "Joseph L Sanguinetti"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/29fkc5wx3zsft.bib",
  "cited_by": 0,
  "doi": "10.31234/osf.io/6gjdp_v1",
  "fulltext_url": null,
  "id": "29fkc5wx3zsft",
  "issns": [],
  "landing_url": "https://osf.io/preprints/psyarxiv/6gjdp_v1/",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "bepress",
      "Behavioral Neuroscience"
    ],
    [
      "bepress",
      "Cognitive Neuroscience"
    ],
    [
      "bepress",
      "Cognitive Psychology"
    ],
    [
      "bepress",
      "Neuroscience"
    ],
    [
      "bepress",
      "Other Neuroscience and Neurobiology"
    ],
    [
      "bepress",
      "Social and Behavioral Sciences"
    ],
    [
      "bepress",
      "Systems Neuroscience"
    ],
    [
      "openalex",
      "3203|Mindfulness and Compassion Interventions"
    ]
  ],
  "openalex": "W7223092131",
  "pdf_url": "https://osf.io/6gjdp/download",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/29fkc5wx3zsft.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "6gjdp",
      "source": "osf",
      "url": "https://osf.io/preprints/psyarxiv/6gjdp_v1/"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "bepress:Cognitive Neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Facilitating Meditation with Focused Ultrasound Neuromodulation: A Sham-Controlled Crossover Study in Long-Term and Novice Meditators",
  "title_text": "Facilitating Meditation with Focused Ultrasound Neuromodulation: A Sham-Controlled Crossover Study in Long-Term and Novice Meditators",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:59Z",
  "url": "https://research.draconitic.com/paper/29fkc5wx3zsft",
  "venue": "PsyArXiv",
  "versions": []
}