{
  "abstract": "Introduction: Aerobic exercise improves disease-free and overall survival in patients with colorectal cancer. This study tested the hypothesis that a key mechanism of action underpinning these survival benefits relates to exercise-induced improvements in inflammation and immunity in colorectal cancer survivors.\n\nMethods: This trial randomized 60 survivors of stage I-III colorectal cancer to 12 weeks of home-based aerobic exercise or control. Endpoints included plasma sCD30, sGP130, IL-1β, and IL-2 measured using bead-based magnetic immunoassays, and the frequencies of circulating T-cell [CD4+ and CD8+ naïve, central memory, effector memory, and terminally differentiated effector memory (TEMRA)] and NK-cell subsets quantified by flow cytometry.\n\nResults: Exercise training reduced sCD30 [−153.1 pg/mL (95% CI: −249.5, −56.7); p=0.014] but did not reduce sGP130, IL-1β, or IL-2 compared to control. Exercise training increased the proportions of resting NKG2D−/NKG2C+ NK-cells [2.75% (95% CI: 0.34, 5.15); p=0.03] and CD56+ bright KLRG1−/NKG2C+ NK-cells [4.46% (95% CI: 1.32, 7.60); p=0.006] compared to control. In the control group, sCD30 inversely correlated with naive CD8+ T-cells [r=−0.51 (95% CI: −0.82, 0.03); p=0.04], whereas sGP130 [r=0.46 (95% CI: −0.09, 0.72); p=0.01] and IL-2 positively correlated with CD8+ TEMRA frequencies [r=0.50 (95% CI: 0.06, 0.78); p=0.02]; these associations were not statistically significant in the exercise group.\n\nConclusion: In this secondary, exploratory analysis of a randomized trial, aerobic exercise reshaped aspects of the inflammatory-immune axis in colorectal cancer survivors. These findings refine our understanding of the biological mechanisms by which exercise may improve disease-free and overall survival in colon cancer survivors.",
  "abstract_shown": true,
  "affiliations": [
    "AdventHealth, Orlando, FL, USA",
    "Pennington Biomedical Research Center, Baton Rouge, LA, USA",
    "LSU School of Kinesiology, Baton Rouge, LA, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Eunhan Cho",
      "orcid": "0000-0002-5002-2932"
    },
    {
      "affs": [
        0
      ],
      "name": "Stephanie L. E. Compton"
    },
    {
      "affs": [
        1
      ],
      "name": "Shengping Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohamedtaki A. Tejani"
    },
    {
      "affs": [
        0
      ],
      "name": "Ahmed Zakari"
    },
    {
      "affs": [
        0
      ],
      "name": "Justin C. Brown"
    },
    {
      "affs": [
        2
      ],
      "name": "Guillaume Spielmann"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/29yhtc5cbyxh3.bib",
  "cited_by": 0,
  "doi": "10.1177/10732748261493127",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735457/",
  "id": "29yhtc5cbyxh3",
  "issns": [
    "1073-2748",
    "1526-2359"
  ],
  "landing_url": "https://doi.org/10.1177/10732748261493127",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2737|Exercise and Physiological Responses"
    ]
  ],
  "openalex": "W7214754097",
  "pdf_url": null,
  "pmcid": "PMC13735457",
  "pmid": "42808444",
  "published": "2026-09-29",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/29yhtc5cbyxh3.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:08Z",
      "native_id": "PMC13735457",
      "source": "pmc",
      "url": "https://doi.org/10.1177/10732748261493127"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Exercise and Physiological Responses",
      "subfield": "physiology"
    }
  ],
  "title": "The Impact of Aerobic Exercise on Circulating T-Cells and NK-Cells in Colorectal Cancer Survivors: A Secondary Analysis of a Randomized Trial",
  "title_text": "The Impact of Aerobic Exercise on Circulating T-Cells and NK-Cells in Colorectal Cancer Survivors: A Secondary Analysis of a Randomized Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:08Z",
  "url": "https://research.draconitic.com/paper/29yhtc5cbyxh3",
  "venue": "Cancer Control: Journal of the Moffitt Cancer Center",
  "versions": []
}