{
  "abstract": "Alongside the rise in obesity and other metabolic dysfunction components, non-alcoholic fatty liver disease (NAFLD) has grown more widespread. Obesity, T2DM and hyperlipidemia are main risk factors. This condition incorporates a wide variety of clinical manifestations, from steatosis, NASH, fibrosis and cirrhosis. MiR-217 exerts a significant influence in numerous biological processes. This study was carried out to examine miR-217 expression and its potential contribution to NAFLD pathophysiology. Thirty patients with NAFLD and thirty healthy controls participated in the current study. The chosen miR-217 expression profile and its possible correlation with clinical and laboratory indicators were assessed using RT-PCR. Our study revealed a significant increase of miR-217 expression in NAFLD patients versus control ones (with a p < 0.0001). Furthermore, according to ROC curve analysis, miR-217 showed outstanding diagnostic ability (AUC of 1, a cutoff point of 1.329, sensitivity and specificity of 100%). There was a substantial negative correlation among miR-217 and free T4 without any significantly observed correlation between miR-217 and other measured variables. In conclusion, significantly higher serum miR-217 levels in NAFLD patient compared to healthy volunteers support the notion that miR-217 is a promising biomarker for NAFLD disease and advance our knowledge of the illness.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Biochemistry Division, Faculty of Science, Fayoum University, El- Fayoum, Egypt",
    "Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Fayoum University, El- Fayoum, Egypt"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ola N. Sayed"
    },
    {
      "affs": [
        1
      ],
      "name": "Azza M. Elamir"
    },
    {
      "affs": [
        0
      ],
      "name": "Esraa A.G. Hamad"
    },
    {
      "affs": [
        0
      ],
      "name": "Mervat M. El-Sayed"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2a0trhywx24g9.bib",
  "cited_by": 0,
  "doi": "10.22099/mbrc.2026.56532.2319",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729772/",
  "id": "2a0trhywx24g9",
  "issns": [
    "2322-181X",
    "2345-2005"
  ],
  "landing_url": "https://doi.org/10.22099/mbrc.2026.56532.2319",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "1306|MicroRNA in disease regulation"
    ]
  ],
  "openalex": "W7225227798",
  "pdf_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729772/pdf/mbrc-15-4-213.pdf",
  "pmcid": "PMC13729772",
  "pmid": "42979478",
  "published": "2026-11-04",
  "publisher": "Shiraz University",
  "ris": "https://research.draconitic.com/paper/2a0trhywx24g9.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:31Z",
      "native_id": "PMC13729772",
      "source": "pmc",
      "url": "https://doi.org/10.22099/mbrc.2026.56532.2319"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|MicroRNA in disease regulation",
      "subfield": "oncology"
    }
  ],
  "title": "Upregulation of serum expression of miR-217 in non alcoholic fatty liver disease",
  "title_text": "Upregulation of serum expression of miR-217 in non alcoholic fatty liver disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:31Z",
  "url": "https://research.draconitic.com/paper/2a0trhywx24g9",
  "venue": "Molecular Biology Research Communications",
  "versions": []
}