{
  "abstract": "In this work, biomimetic scaffolds designed to mimic the microstructure of human skin were fabricated by electrospinning using polyvinyl alcohol (PVA), sodium alginate (SA), and hydroxyapatite-dysprosium oxide (Hap/Dy2O3). Hap was synthesized by a hydrothermal method with Dy2O3 contents of 0, 0.5, 1.0, 1.5, and 2.0 wt%. The resulting electrospun PVA/SA scaffolds incorporating Dy2O3-decorated Hap exhibited hydrophilic behavior and structural stability through ionic crosslinking. Morphological analysis by scanning electron microscopy revealed mean fibre diameters ranging from 0.43 to 1.47 µm across the scaffold formulations. Structural and compositional analyses using Fourier transform infrared spectroscopy and thermogravimetric analysis confirmed the preservation of the characteristic phosphate bands of Hap and the structural stability of the scaffold components. Cytocompatibility was evaluated in human keratinocytes using calcein AM and ethidium homodimer staining. Quantitative analysis indicated that all formulations maintained cell viability above the ISO 10993-5 threshold. These results demonstrate that the developed electrospun scaffolds provide a suitable microenvironment for keratinocyte growth while preserving the multifunctional characteristics associated with Dy2O3-containing biomaterials.",
  "abstract_shown": true,
  "affiliations": [
    "Área Académica de Ciencias de la Tierra y Materiales, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo Carretera Pachuca-Tulancingo Km. 4.5 42184 México",
    "Investigadoras e Investigadores por México, SECIHTI Av. Insurgentes Sur 1582, Col. Crédito Constructor, Alcaldía Benito Juárez Ciudad de México 03940 México",
    "Instituto de Física, Universidad Autónoma de San Luis Potosí Av. Parque Chapultepec 1570, Privadas del Pedregal San Luis Potosí, SLP 78295 México",
    "Facultad de Ingeniería Química, Benemérita Universidad Autónoma de Puebla Av. San Claudio S/N C.P. 72570.1 México"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "S. Ruiz-Salgado"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "D. Salado-Leza"
    },
    {
      "affs": [
        3
      ],
      "name": "M. Morales-Sánchez"
    },
    {
      "affs": [
        2
      ],
      "name": "D. Sánchez-Campos"
    },
    {
      "affs": [
        3
      ],
      "name": "E. Rubio-Rosas"
    },
    {
      "affs": [
        0
      ],
      "name": "S. López Ortiz"
    },
    {
      "affs": [
        0
      ],
      "name": "V. Rodríguez-Lugo",
      "orcid": "0000-0001-8767-032X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2azwk5f79nt95.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra02214f",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673665/?tool=EBI",
  "id": "2azwk5f79nt95",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13673665",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2502|Electrospun Nanofibers in Biomedical Applications"
    ]
  ],
  "openalex": "W7222642772",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673665/pdf/?tool=EBI",
  "pmcid": "PMC13673665",
  "pmid": "42891176",
  "published": "2026-10-16",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/2azwk5f79nt95.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:25Z",
      "native_id": "PMC:PMC13673665",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13673665"
    },
    {
      "first_seen": "2026-11-07T12:23:32Z",
      "native_id": "PMC13673665",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra02214f"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Electrospun Nanofibers in Biomedical Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Evaluation of keratinocyte viability on polyvinyl alcohol/sodium alginate/(hydroxyapatite/dysprosium oxide) scaffolds",
  "title_text": "Evaluation of keratinocyte viability on polyvinyl alcohol/sodium alginate/(hydroxyapatite/dysprosium oxide) scaffolds",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:23:32Z",
  "url": "https://research.draconitic.com/paper/2azwk5f79nt95",
  "venue": "RSC advances",
  "versions": []
}