{
  "abstract": "Background: The aim of the study was to characterize the expression of nuclear factor (NF)-κB signaling pathway molecules in the septal mucosa of type I intestinal atresia (IA) and to explore their potential association with impaired intestinal recanalization during embryonic development.\n\nMethods: Septa and adjacent proximal intestinal wall tissue were obtained from eight patients with type I IA. Serial sections were prepared for immunohistochemistry staining of transforming growth factor-β-activated kinase 1 (TAK1), I kappa B kinase-alpha/beta (IKK-α/β), p65 NF-κB, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). Mean optical density was quantified using Image-Pro Plus software, and differences between groups were statistically analyzed.\n\nResults: TAK1, IKK-α/β, and p65 NF-κB showed weak cytoplasmic immunoreactivity in the glandular epithelial cells of the control intestinal mucosa. In contrast, markedly increased cytoplasmic staining for TAK1, IKK-α/β, and p65 NF-κB proteins was observed in the mucosal glands of septa. The expression of TNF-α and IL-6, typical downstream pro-inflammatory cytokines of the NF-κB signaling pathway, demonstrated markedly increased cytoplasmic staining. A semiquantitative analysis confirmed a significantly higher expression of TAK1, IKK-α/β, p65 NF-κB, TNF-α, and IL-6 in septa than in the normal intestinal wall.\n\nConclusion: The aberrant expression of the NF-κB signaling pathway and activation of the inflammatory response during embryonic intestinal recanalization may be associated with the formation and progression of septa.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Surgery, Capital Center for Children’s Health, Capital Medical University, Capital Institute of Pediatrics , ,",
    "Department of Pathology, Beijing Children’s Hospital Heilongjiang Hospital , ,",
    "Department of Science and Technology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics , ,",
    "Department of Neonatal Surgery, Capital Center for Children’s Health, Capital Medical University, Capital Institute of Pediatrics , ,",
    "Department of Biochemistry and Immunology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xuelai Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Huan Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuqiang Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Mao Ye"
    },
    {
      "affs": [
        2
      ],
      "name": "Xiaoyun Cui"
    },
    {
      "affs": [
        3
      ],
      "name": "Yandong Wei"
    },
    {
      "affs": [
        4
      ],
      "name": "Feng He"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2b9d4hxkbkv1r.bib",
  "cited_by": 0,
  "doi": "10.3389/fped.2026.1978002",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724578/?tool=EBI",
  "id": "2b9d4hxkbkv1r",
  "issns": [
    "2296-2360"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13724578",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2746|Congenital gastrointestinal and neural anomalies"
    ]
  ],
  "openalex": "W7222938433",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724578/pdf/?tool=EBI",
  "pmcid": "PMC13724578",
  "pmid": "42973596",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2b9d4hxkbkv1r.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13724578",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13724578"
    },
    {
      "first_seen": "2026-11-04T12:23:07Z",
      "native_id": "PMC13724578",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fped.2026.1978002"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42973596",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973596"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Congenital gastrointestinal and neural anomalies",
      "subfield": "surgery"
    }
  ],
  "title": "Immunohistochemical expression of NF-κB signaling pathway components in the septum of type I intestinal atresia",
  "title_text": "Immunohistochemical expression of NF-κB signaling pathway components in the septum of type I intestinal atresia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:21:18Z",
  "url": "https://research.draconitic.com/paper/2b9d4hxkbkv1r",
  "venue": "Frontiers in pediatrics",
  "versions": []
}