{
  "abstract": "Second near-infrared (NIR-II; 1000 to 1700 nanometers) aggregation-induced emission luminogens (AIEgens) hold great promise for imaging-guided precision tumor phototherapy yet are limited by the intrinsic trade-off between fluorescence brightness and photothermal performance. Existing design strategies often yield complex molecular structures while inadequately addressing this trade-off. Herein, we propose a “Minor Tweaks, Major Leaps” concept: Simple modification of the star NIR-II AIEgen 2TT- o C6B (less than 5% change in molecular weight) markedly improves both NIR-II fluorescence brightness and photothermal performance. The thus-obtained new NIR-II AIEgen, ST-CZ , ranks among leading phototheranostic agents, exhibiting a long emission maximum at 1082 nanometers, a high fluorescence quantum yield of 4.3%, and a great photothermal conversion efficiency of 69% in nanoparticles. Leveraging these superior properties, ST-CZ enables cerebrovascular imaging with an advanced resolution of 19.0 micrometers, and the derived multifunctional platform achieves tumor progression–associated vascular remodeling visualization and efficient metastatic tumor ablation via synergistic photothermal immunotherapy. This work provides a robust strategy for developing high-performance NIR-II AIEgens for advanced biomedical applications.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Integrated Optoelectronics, Key Laboratory of Advanced Gas Sensors of Jilin Province, College of Electronic Science and Engineering, College of Integrated Circuits, Jilin University, Changchun 130012, China.",
    "Laboratory Animal Center, College of Animal Science, Jilin University, Changchun 130021, China.",
    "Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Jilin University, Changchun 130033, China.",
    "College of Chemistry, Jilin University, Changchun 130012, China.",
    "International Center of Future Science, Jilin University, Changchun 130012, China.",
    "Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Shenzhen 518172, Guangdong, China."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Huanlong Zheng",
      "orcid": "0009-0002-0191-0965"
    },
    {
      "affs": [
        1
      ],
      "name": "Tiantian Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Tong Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiahang Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinbei Wei",
      "orcid": "0000-0002-5977-5527"
    },
    {
      "affs": [
        3
      ],
      "name": "Shi-Tong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chenguang Wang",
      "orcid": "0000-0001-9770-1062"
    },
    {
      "affs": [
        1
      ],
      "name": "Dongxu Wang",
      "orcid": "0000-0003-0464-1596"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Geyu Lu",
      "orcid": "0000-0003-1958-2867"
    },
    {
      "affs": [
        5
      ],
      "name": "Ben Zhong Tang",
      "orcid": "0000-0002-0293-964X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2bnm2ppqv06c8.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aeh5939",
  "fulltext_url": null,
  "id": "2bnm2ppqv06c8",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aeh5939",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Luminescence and Fluorescent Materials"
    ]
  ],
  "openalex": "W7214986161",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/2bnm2ppqv06c8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aeh5939",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aeh5939"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Luminescence and Fluorescent Materials",
      "subfield": "materials-polymers"
    }
  ],
  "title": "A NIR-II AIEgen with superior fluorescence and photothermal performance for precision theranostics",
  "title_text": "A NIR-II AIEgen with superior fluorescence and photothermal performance for precision theranostics",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:41Z",
  "url": "https://research.draconitic.com/paper/2bnm2ppqv06c8",
  "venue": "Science Advances",
  "versions": []
}