{
  "abstract": "Structured AbstractO_ST_ABSImportanceC_ST_ABSUpper extremity impairment is a leading cause of post-stroke disability, yet clinically approved neuromodulation therapies are currently limited by the risks and costs of surgical implantation. There is an unmet need for non-invasive brain stimulation.\n\nObjectiveTo evaluate the feasibility, safety, and preliminary clinical efficacy of a novel form of non-invasive brain stimulation, kilohertz transcranial magnetic perturbation (kTMP), for upper limb motor recovery after stroke.\n\nDesignA single-center, open-label trial was conducted between September 2025 and April 2026 and comprised a 4-week standard-of-care baseline period, 4 weeks of active treatment with kTMP combined with motor training, and a 4-week follow-up.\n\nSettingAcademic research center.\n\nParticipantsSeven individuals with chronic stroke and upper extremity motor deficits. Intervention: Four weeks of kTMP (3 sessions/week), a brain stimulation approach using magnetic induction to generate subthreshold electric fields, paired with motor tasks.\n\nMain OutcomesChange in Fugl-Meyer Assessment for Upper Extremity (FMA-UE) scores across study periods (standard-of-care baseline, active treatment, follow up). Secondary outcomes included measures of movement smoothness (Spectral Arc Length, SPARC) and fragmentation (mean velocity peak count), and intervention tolerability ratings.\n\nResultsAcross 7 participants (mean [SD] age, 57.4 [8.7] years; 4 males; mean [SD] time poststroke, 3.5 [2.1] years). No device-related adverse events occurred, and the intervention was well-tolerated (participants rated sensation intensity at an average of less than 0.5 on a 0-10 scale). FMA-UE scores remained stable during the baseline period (mean change, +0.14 points; 95% CI, -1.21 to 1.50; adjusted P =.98), increased significantly following the kTMP-intervention (mean change, +7.00 points; 95% CI, 5.31 to 8.69; adjusted P =.047), and were sustained at the 4-week follow-up (mean change, -1.33 points; 95% CI, -2.42 to -0.25; adjusted P =.13). Movement smoothness improved significantly within 1 week of kTMP onset (mean change, 1.48 points; 95% CI, 0.49-2.47; adjusted P =.03); movement fragmentation showed a similar but nonsignificant trend.\n\nConclusions and RelevanceThis pilot trial provides preliminary evidence that kTMP combined with motor tasks is safe, feasible, and may support upper extremity recovery. These pilot data warrant large, randomized controlled trials to evaluate efficacy in support of poststroke motor recovery.\n\nTrial Registration: ClinicalTrials.gov IdentifierNCT06317194\n\nKey PointsO_ST_ABSQuestionC_ST_ABSIs kilohertz transcranial magnetic perturbation (kTMP) a safe, feasible, and effective non-invasive intervention for improving upper extremity motor recovery in chronic stroke?\n\nFindingsIn this single-center, open-label pilot trial of 7 participants with chronic stroke, upper extremity motor impairment (FMA-UE) remained stable during a 4-week baseline period and significantly improved (mean change, +7.0 points) following 4 weeks of active kTMP treatment combined with motor tasks, with gains sustained at 4-week follow-up. No device-related adverse events occurred.\n\nMeaningThese preliminary findings suggest that kTMP is safe and feasible and may support upper extremity motor recovery after stroke, warranting further evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, University of California San Francisco"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "C. M. Merrick"
    },
    {
      "name": "F. Dai"
    },
    {
      "name": "S. Singh"
    },
    {
      "name": "I. O'Kidhain"
    },
    {
      "name": "P. Reber"
    },
    {
      "name": "C. Luu"
    },
    {
      "name": "A. V. Peterchev"
    },
    {
      "name": "D. Sheltraw"
    },
    {
      "name": "R. B. Ivry"
    },
    {
      "name": "L. Labruna"
    },
    {
      "affs": [
        0
      ],
      "name": "K. Ganguly"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2bq5tbx25cw26.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.05.26364594",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.05.26364594v1.full",
  "id": "2bq5tbx25cw26",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.05.26364594v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "neurology"
    ],
    [
      "openalex",
      "2808|Transcranial Magnetic Stimulation Studies"
    ]
  ],
  "openalex": "W7221317723",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.05.26364594v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2bq5tbx25cw26.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:22Z",
      "native_id": "10.64898/2026.10.05.26364594",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.05.26364594v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Kilohertz Transcranial Magnetic Perturbation (kTMP) for Upper Extremity Motor Recovery After Stroke: A Nonrandomized Pilot Trial",
  "title_text": "Kilohertz Transcranial Magnetic Perturbation (kTMP) for Upper Extremity Motor Recovery After Stroke: A Nonrandomized Pilot Trial",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:22Z",
  "url": "https://research.draconitic.com/paper/2bq5tbx25cw26",
  "venue": "medRxiv",
  "versions": []
}