{
  "abstract": "In the present study, a trimetallic Au/Pt/Cu nanofluid was synthesized via a rapid one-pot microwave-assisted strategy and systematically evaluated for multifunctional biomedical activity. Structural and spectroscopic characterization confirmed the formation of an integrated multimetallic nanostructure, likely to contain alloyed or compositionally mixed domains that generate synergistically active interfaces of Au, Pt and Cu. The nanofluid exhibited broad-spectrum antimicrobial activity, inhibiting Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) with a minimum inhibitory concentration (MIC) of 0.0137 µmol mL−1. Enhanced antifungal efficacy was observed against Rhizopus oryzae and Candida albicans (MIC = 0.0068 µmol mL−1), with activity against C. albicans surpassing that of fluconazole under identical conditions. The anti-inflammatory potential evaluated through bovine serum albumin denaturation revealed an IC50 of 14.88 ± 0.09 µM, while antioxidant capacity measured using the DPPH assay showed an IC50 of 4.34 ± 0.08 µM, indicating effective free-radical scavenging in the low-micromolar range. These findings highlight a synergy-driven mechanism integrating catalytic redox modulation, biomolecular interactions, and enhanced physicochemical compatibility.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physics, University of Allahabad Prayagraj-211002 Uttar Pradesh India",
    "Department of Chemistry, Swansea University Singleton Park Campus Swansea SA2 8PP UK",
    "Center of Agriculture, Food, Environment, University of Trento San Michele all’Adige 38010 Italy",
    "Department of Chemistry, Guru Jambheshwar University of Science and Technology Hisar-125001 India",
    "Department of Chemistry, Baba Raghav Das Post Graduate College Deoria-274001 Uttar Pradesh India",
    "Institute of Pharmaceutical Science, King's College London Franklin-Wilkins Building, Stamford Street SE1 9NH London UK",
    "Department of Chemical Engineering, Swansea University Bay Campus Swansea SA1 8EN UK",
    "Department of Chemistry, University of Lucknow Lucknow-226007 Uttar Pradesh India"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Navneet Yadav",
      "orcid": "0000-0001-9638-056X"
    },
    {
      "affs": [
        2
      ],
      "name": "Amara Rafi"
    },
    {
      "affs": [
        1
      ],
      "name": "Lalan Kumar"
    },
    {
      "affs": [
        3
      ],
      "name": "Binesh Kumar"
    },
    {
      "affs": [
        4
      ],
      "name": "Sikandar Paswan",
      "orcid": "0000-0002-5815-1819"
    },
    {
      "affs": [
        0
      ],
      "name": "Ajit Kumar Maddheshiya"
    },
    {
      "affs": [
        3
      ],
      "name": "Jai Devi",
      "orcid": "0000-0003-4512-6742"
    },
    {
      "affs": [
        5
      ],
      "name": "Nikunj Patel"
    },
    {
      "affs": [
        6
      ],
      "name": "Afsanehsadat Larimi",
      "orcid": "0000-0001-5566-171X"
    },
    {
      "affs": [
        7
      ],
      "name": "Bharat Kumar",
      "orcid": "0000-0002-4086-3754"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2cyxf0vy23tb8.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra06054d",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13650930/",
  "id": "2cyxf0vy23tb8",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://doi.org/10.1039/d6ra06054d",
  "language": "en",
  "licence": "CC-BY-3.0",
  "licence_label": "CC BY 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2504|Gold and Silver Nanoparticles Synthesis and Applications"
    ]
  ],
  "openalex": "W7221147252",
  "pdf_url": null,
  "pmcid": "PMC13650930",
  "pmid": "42857571",
  "published": "2026-10-09",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/2cyxf0vy23tb8.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:34Z",
      "native_id": "PMC13650930",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra06054d"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2504|Gold and Silver Nanoparticles Synthesis and Applications",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Synergistic multifunctional biomedical activity of microwave-synthesized Au/Pt/Cu trimetallic nanofluids: experimental and DFT insights",
  "title_text": "Synergistic multifunctional biomedical activity of microwave-synthesized Au/Pt/Cu trimetallic nanofluids: experimental and DFT insights",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:20:48Z",
  "url": "https://research.draconitic.com/paper/2cyxf0vy23tb8",
  "venue": "RSC Advances",
  "versions": []
}