{
  "abstract": "Glioma is characterized by profound metabolic reprogramming and sustained lactate accumulation; however, the mechanisms by which lactate-rich metabolic stress is translated into stable malignant phenotypes remain incompletely understood. Lysine lactylation (Kla), a recently identified post-translational modification, has emerged as a critical nexus linking lactate metabolism to durable epigenetic and protein-state adaptations. In glioma, accumulating evidence indicates that Kla contributes to multiple dimensions of tumor biology, including oncogenic transcriptional activation, glioma stem-like cell (GSC) maintenance, immunosuppressive remodeling, and therapeutic resistance. Mechanistically, histone Kla rewires metabolic stress-responsive transcriptional programs, whereas non-histone Kla executes rapid, transcription-independent responses by directly modifying key regulatory proteins involved in DNA repair, signal transduction, and metabolic adaptation. This review systematically summarizes current progress on the lactate-Kla axis in glioma, encompassing the basis of lactate metabolism, the molecular regulatory network of Kla, and the distinct yet coordinated functions of histone and non-histone lactylation. We further discuss how Kla contributes to temozolomide (TMZ) resistance, radioresistance, and chemoradiotherapy adaptation, and outline a hierarchical therapeutic framework targeting this pathway. Despite rapid advances, important areas requiring further investigation include subtype-specific variation in lactate-Kla biology and the potential crosstalk between Kla and other post-translational modifications. A better understanding of these issues will help define the biological significance of the lactate-Kla axis and guide the future development of lactylation-based therapeutic strategies in glioma.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, China.",
    "Jinfeng Laboratory, Chongqing, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiaosong Hu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Li Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yanghao Hu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hongjuan Cui"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2d0grnh4rhxk6.bib",
  "cited_by": 0,
  "doi": "10.3389/fcell.2026.1821274",
  "fulltext_url": "https://europepmc.org/articles/PMC13696035",
  "id": "2d0grnh4rhxk6",
  "issns": [
    "2296-634X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928918",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1306|Cancer, Hypoxia, and Metabolism"
    ]
  ],
  "openalex": "W7221458394",
  "pdf_url": "https://europepmc.org/articles/PMC13696035?pdf=render",
  "pmcid": "PMC13696035",
  "pmid": "42928918",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2d0grnh4rhxk6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928918",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928918"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer, Hypoxia, and Metabolism",
      "subfield": "oncology"
    }
  ],
  "title": "Lysine lactylation in glioma: from metabolic stress to epigenetic remodeling and therapeutic resistance.",
  "title_text": "Lysine lactylation in glioma: from metabolic stress to epigenetic remodeling and therapeutic resistance.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/2d0grnh4rhxk6",
  "venue": "Frontiers in cell and developmental biology",
  "versions": []
}