{
  "abstract": "Structured AbstractO_ST_ABSAimsC_ST_ABSTo characterize adults with obesity in a large integrated health system.\n\nMethodsWe created a cross-sectional cohort of adults with at least one body mass index (BMI) value >=30 kg/m2 in the prior 18 months, a recent in-person outpatient visit, and an assigned primary care provider. Electronic health record data were transformed into a patient-level analytic dataset and linked to neighborhood-level social determinants of health. Diagnoses, laboratory values, vital signs, and prescriptions were curated using reproducible phenotype definitions and internally reviewed vocabularies.\n\nResultsThe registry included 280,186 adults, of whom 48% had class I obesity. The cohort was 63% female, 27% Black, and 14% lived in areas with high or very high deprivation. Common comorbidities included hypertension, type 2 diabetes, depression, and anxiety. HbA1c and cholesterol measurements were absent in more than 40% of the cohort during the prior two years. Overall, 22% of patients received a prescription for at least one weight loss drug in the past 2 years, including 18% who received a weight-loss-approved GLP-1 receptor agonist.\n\nConclusionsThis care-engaged obesity cohort was characterized by high representation of women and socially vulnerable populations, substantial cardiometabolic screening gaps, and broad adoption of GLP-1 agonists.",
  "abstract_shown": true,
  "affiliations": [
    "Wake Forest University School of Medicine"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "B. J. Wells"
    },
    {
      "name": "K. M. Lenoir"
    },
    {
      "name": "M. Webster-Clark"
    },
    {
      "name": "N. M. Pajewski"
    },
    {
      "affs": [
        0
      ],
      "name": "A. T. Pons-Junkins"
    },
    {
      "name": "M. M. Mielke"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2dac2gnegyyfg.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.04.26361064",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26361064v1.full",
  "id": "2dac2gnegyyfg",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26361064v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "endocrinology"
    ],
    [
      "openalex",
      "2736|Pharmacology and Obesity Treatment"
    ]
  ],
  "openalex": "W7212083397",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26361064v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2dac2gnegyyfg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:03Z",
      "native_id": "10.64898/2026.09.04.26361064",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26361064v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:endocrinology",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Obesity in the GLP-1 Era: Clinical Characteristics and Prescribing Patterns in a Large Integrated Health System",
  "title_text": "Obesity in the GLP-1 Era: Clinical Characteristics and Prescribing Patterns in a Large Integrated Health System",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:03Z",
  "url": "https://research.draconitic.com/paper/2dac2gnegyyfg",
  "venue": "medRxiv",
  "versions": []
}