{
  "abstract": "Biofilm formation is an important pathogenic process that contributes to bacterial virulence, persistence, and reduced susceptibility to antimicrobial treatment. Therefore, taxifolin was evaluated as a potential antibiofilm agent. Taxifolin was assessed for its effects on biofilm formation, planktonic growth, antibiotic susceptibility, and the expression of biofilm- and virulence-associated genes. Taxifolin inhibited biofilm formation by Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Streptococcus mutans, Streptococcus sobrinus, Staphylococcus aureus, Pseudomonas aeruginosa, Cutibacterium acnes, and Porphyromonas gingivalis (IC50, 0.065~0.79 µg/mL). In E. faecalis and E. faecium, taxifolin did not substantially affect planktonic growth at 10 µg/mL. Taxifolin enhanced the antibacterial activity of commercially available antibiotics, and downregulated the expression of cytolysin-associated genes (cylR, cylM, and cylLs), quorum-sensing genes (fsrB and fsrC), biofilm-associated genes (gelE, acm, scm, ebpA, ebpB and bps), and the biofilm-associated virulence gene Esp. Taxifolin inhibited biofilm formation, enhanced bacterial susceptibility, and attenuated virulence-associated gene expression, supporting its potential as an adjunctive antibiofilm therapy for the management of biofilm-associated bacterial infections. Further studies are required to define its mechanism of action, activity against established biofilms, pharmacological properties, safety, and efficacy in appropriate in vivo models.",
  "abstract_shown": true,
  "affiliations": [
    "Graduate School of Biotechnology, Kyung Hee University, Seocheon, Giheung, Yongin 17104, Gyeonggi-do, Republic of Korea",
    "Major in Bio-Cosmetic Engineering, Division of Convergence Studies, Sungkyul University, 53 Sungkyuldaehak-ro, Manan-gu, Anyang-si 14097, Gyeonggi-do, Republic of Korea"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ji-Hyun Yoon",
      "orcid": "0009-0006-8761-5914"
    },
    {
      "affs": [
        1
      ],
      "name": "Yeo-Jin Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Ki-Young Kim",
      "orcid": "0000-0002-0407-3018"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2e4h7ggjnf6v3.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219469",
  "fulltext_url": null,
  "id": "2e4h7ggjnf6v3",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9469",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Bacterial biofilms and quorum sensing"
    ]
  ],
  "openalex": "W7223793643",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/2e4h7ggjnf6v3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27219469",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9469"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bacterial biofilms and quorum sensing",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Taxifolin Attenuates Bacterial Pathogenicity and Thereby Enhances Antibacterial Efficacy in Clinically Relevant Bacteria",
  "title_text": "Taxifolin Attenuates Bacterial Pathogenicity and Thereby Enhances Antibacterial Efficacy in Clinically Relevant Bacteria",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:57Z",
  "url": "https://research.draconitic.com/paper/2e4h7ggjnf6v3",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}