{
  "abstract": "Castleman disease (CD) represents a heterogeneous group of hematologic disorders characterized by distinct histopathological features. While CD is regarded as a pre-lymphomatous condition, its reactive or neoplastic nature is still a matter of controversy. Although rare, lymphoma has been reported in patients with CD, most commonly B-cell lymphomas. Here, we present a case of a 69-year-old man initially diagnosed with CD who subsequently developed angioimmunoblastic T-cell lymphoma (AITL) during treatment. To elucidate the potential biological relationship between these two disease entities, we performed whole-exome sequencing to compare genomic alterations between the two disease states. Additionally, we provide a concise review of published cases documenting lymphoma occurring after or coexisting with CD, summarizing patients’ characteristics and the various treatment strategies employed thus far.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00277-026-07199-3.",
  "abstract_shown": true,
  "affiliations": [
    "Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310006 China"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ruyi Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xi Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jia Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinuo Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Duoduo Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoyan Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhen Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenjun Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2e9aknkr6grc5.bib",
  "cited_by": 0,
  "doi": "10.1007/s00277-026-07199-3",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696607/",
  "id": "2e9aknkr6grc5",
  "issns": [
    "0939-5555",
    "1432-0584"
  ],
  "landing_url": "https://doi.org/10.1007/s00277-026-07199-3",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "lcc",
      "RC31-1245"
    ],
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7171579286",
  "pdf_url": "https://europepmc.org/articles/PMC13696607?pdf=render",
  "pmcid": "PMC13696607",
  "pmid": "42928392",
  "published": "2026-07-01",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/2e9aknkr6grc5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "PMC13696607",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00277-026-07199-3"
    },
    {
      "first_seen": "2026-10-30T12:21:20Z",
      "native_id": "MED:42928392",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928392"
    },
    {
      "first_seen": "2026-11-01T14:21:16Z",
      "native_id": "0351f482ea6e431dbd33f13ea347630e",
      "source": "doaj",
      "url": "https://doi.org/10.1007/s00277-026-07199-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Lymphoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Angioimmunoblastic T-cell lymphoma following Castleman’s disease: diagnostic challenges and literature review",
  "title_text": "Angioimmunoblastic T-cell lymphoma following Castleman’s disease: diagnostic challenges and literature review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T14:20:43Z",
  "url": "https://research.draconitic.com/paper/2e9aknkr6grc5",
  "venue": "Annals of Hematology",
  "versions": []
}