{
  "abstract": "Sorafenib is an oral multikinase inhibitor approved for advanced hepatocellular carcinoma, renal cell carcinoma, and maintenance therapy in selected patients with FMS-like tyrosine kinase (FLT3)-mutated acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation. We report the case of a 35-year-old woman with FLT3 internal tandem duplication (FLT3-ITD) and nucleophosmin 1 (NPM1)-positive acute myeloid leukemia (AML) who developed painful hyperkeratotic plantar plaques approximately eight weeks after initiating sorafenib therapy. Clinical examination revealed multiple symmetrical hyperkeratotic plaques involving the pressure-bearing areas of both soles, associated with pain and tenderness, resulting in significant impairment of daily activities. She was diagnosed with sorafenib-induced hand-foot skin reaction (HFSR) and was managed with topical keratolytic and corticosteroid therapy. This case highlights the importance of early recognition and prompt management of sorafenib-induced HFSRs to minimize morbidity and maintain oncological treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Dermatology, Venereology and Leprosy, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Christa Davis"
    },
    {
      "affs": [
        0
      ],
      "name": "Arun Vignesh"
    },
    {
      "affs": [
        0
      ],
      "name": "Sudha Rangarajan"
    },
    {
      "affs": [
        0
      ],
      "name": "Murugan Sundaram"
    },
    {
      "affs": [
        0
      ],
      "name": "Adikrishnan Swaminathan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2ey4wy8z3sj01.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.116921",
  "fulltext_url": "https://europepmc.org/articles/PMC13696053",
  "id": "2ey4wy8z3sj01",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928832",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Chemotherapy-related skin toxicity"
    ]
  ],
  "openalex": "W7214405467",
  "pdf_url": "https://europepmc.org/articles/PMC13696053?pdf=render",
  "pmcid": "PMC13696053",
  "pmid": "42928832",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2ey4wy8z3sj01.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928832",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928832"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Chemotherapy-related skin toxicity",
      "subfield": "general"
    }
  ],
  "title": "Sorafenib-Induced Hand-Foot Skin Reaction in a Patient With Acute Myeloid Leukemia Following Haploidentical Stem Cell Transplantation: A Case Report.",
  "title_text": "Sorafenib-Induced Hand-Foot Skin Reaction in a Patient With Acute Myeloid Leukemia Following Haploidentical Stem Cell Transplantation: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/2ey4wy8z3sj01",
  "venue": "Cureus",
  "versions": []
}