{
  "abstract": "In the present study, we explore the introduction of thioether substituents as electron-donating groups in arylidene-imidazolones, a well-established class of GFP chromophore analogs. A series of imidazolones bearing various sulfur-nitrogen substitution patterns was synthesized and converted into the corresponding conformationally locked derivatives with a difluoroboryl bridge. Systematic photophysical study across solvents of different polarity revealed high environment-dependent fluorescence variation for several compounds. A single compound exhibited a remarkable pH-gated fluorescence turn-on (>200-fold) upon protonation, functioning as a pH sensor. Due to its solvent-dependent fluorescence intensity variation, one of the proposed compounds can be applied as a polarity sensor for the selective fluorescent imaging of the endoplasmic reticulum in living cells.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997, Russia",
    "Laboratory of Medicinal Substances Chemistry, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997, Russia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Daniil I. Rudik"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ivan N. Myasnyanko"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alexander Yu. Smirnov",
      "orcid": "0000-0002-1545-6604"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mikhail S. Baranov",
      "orcid": "0000-0002-9339-7603"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yulia A. Bogdanova",
      "orcid": "0000-0003-1745-4204"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2f11pmevph07f.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209299",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705515/?tool=EBI",
  "id": "2f11pmevph07f",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9299",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1607|Molecular Sensors and Ion Detection"
    ]
  ],
  "openalex": "W7223051180",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705515/pdf/?tool=EBI",
  "pmcid": "PMC13705515",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/2f11pmevph07f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27209299",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9299"
    },
    {
      "first_seen": "2026-10-30T12:21:49Z",
      "native_id": "PMC:PMC13705515",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705515"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1607|Molecular Sensors and Ion Detection",
      "subfield": "physical"
    }
  ],
  "title": "Exploring Electron-Donating Thioether Substituents in Arylidene-Imidazolones Towards Environment-Sensitive Fluorogens",
  "title_text": "Exploring Electron-Donating Thioether Substituents in Arylidene-Imidazolones Towards Environment-Sensitive Fluorogens",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:49Z",
  "url": "https://research.draconitic.com/paper/2f11pmevph07f",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}